Millipore/14-597 |组蛋白H2A.Z蛋白，重组人，100µg/14-597/100µ；G
市场价：
¥0.00
美元价：
0.00
产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 14-597 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | HistoneH2A.ZProtein,humanrecombinant,100µg |
| Overview | RecombinanthumanhistoneH2A.Z |
| ProductInformation |
|---|
| StorageandShippingInformation | |
|---|---|
| StorageConditions | 2yearsat4°C |
| Applications | |
|---|---|
| Application | RecombinanthumanhistoneH2A.Z,producedinE.coli,purifiedbyionexchangechromotography.ForuseinKinaseAssays. |
| KeyApplications |
|
| BIOLOGicalInformation | |
|---|---|
| Source | producedinE.coli |
| SpecificActivity | ForSpecificActivitydata,refertotheCertificateofAnalysisforindividuallotsofthisenzyme. |
| EntrezGeneNumber | |
| EntrezGeneSummary | HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.Thisgeneencodesareplication-independentmemberofthehistoneH2Afamilythatisdistinctfromothermembersofthefamily.StudiesinmicehaveshownthatthisparticularhistoneisrequiredforembryonicdevelopmentandindicatethatlackoffunctionalhistoneH2Aleadstoembryoniclethality. |
| GeneSymbol |
|
| PurificationMethod | Ion-exchangechromatography |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P0C0S5#VarianthistoneH2AwhichreplacesconventionalH2Ainasubsetofnucleosomes.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.Maybeinvolvedintheformationofconstitutiveheterochromatin.Mayberequiredforchromosomesegregationduringcelldivision. SIZE:128aminoacids;13553Da SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.H2AoritsvariantH2AFZformsanheterodimerwithH2B.H2AFZinteractswithINCENP(Bysimilarity). SUBCELLULARLOCATION:Nucleus. PTM:MonoubiquitinationofLys-122givesaspecifictagforepigenetictranscriptionalrepression.&AcetylatedonLys-5,Lys-8andLys-12duringinterphase.Acetylationdisappearsatmitosis(Bysimilarity).&Notphosphorylated(Bysimilarity). SIMILARITY:SwissProt:P0C0S5##BelongstothehistoneH2Afamily. |
| MolecularWeight | 16kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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