Millipore/MABT134 |抗VE钙粘蛋白抗体，克隆BV6/MABT134/100µ；L
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MABT134 |
| Replaces | MAB1989 |
| Description | Anti-VE-cadherinAntibody,cloneBV6 |
| AlternateNames |
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| BackgroundInformation | HumanVascularEndothelial(VE)-cadherinisacalcium-dependentadhesionmoleculestrictlylocatedatcell-to-celljunctions.VE-cadherinispresentinalltypesofendothelium(veins,arteries,capillaryandlargevessels).Cadherinsarecalciumdependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells.Cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.VE-cadherinmayplayanimportantroleinendothelialcellBIOLOGythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.VE-cadherinalsoassociateswithalpha-cateninformingalinktotheCytoskeleton. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgG2aκinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. |
| BiologicalInformation | |
|---|---|
| Immunogen | HUVECcells |
| Clone | BV6 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Isotype | IgG2aκ |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneisaclassicalcadherinfromthecadherinsuperfamilyandislocatedinasix-cadherinclusterinaregiononthelongarmofchromosome16thatisinvolvedinlossofheterozygosityeventsinbreastandprostatecancer.Theencodedproteinisacalcium-dependentcell-celladhesionglycoproteincomprisedoffiveextracellularcadherinrepeats,atransmembraneregionandahighlyconservedcytoplasmictail.FunctioningasaclassiccadherinbyimpartingtocellstheABIlitytoadhereinahomophilicmanner,theproteinmayplayanimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Analternativesplicevarianthasbeendescribedbutitsfulllengthsequencehasnotbeendetermined. |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Cadherinsarecalciumdependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.Thiscadherinmayplayaimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Itassociateswithalpha-cateninformingalinktothecytoskeleton.ActsinconcertwithKRIT1toestablishandmaintaincorrectendothelialcellpolarityandvascularlumen.TheseeffectsaremediatedbyrecruitmentandactivationoftheParpolaritycomplexandRAP1B.RequiredforactivationofPRKCZandforthelocalizationofphosphorylatedPRKCZ,PARD3,TIAM1andRAP1Btothecelljunction. SUBUNITSTRUCTURE:Interactsviacadherin5domainwithPTPRB.InteractswithTRPC4.InteractswithKRIT1. SUBCELLULARLOCATION:Celljunction.Cellmembrane;Single-passtypeImembraneprotein.Note:Foundatcell-cellboundariesandprobablyatcell-matrixboundaries.KRIT1andCDH5reciprocallyregulatetheirlocalizationtoendothelialcell-celljunctions. |
| MolecularWeight | ~120kDaobserved. Thecalculatedmolecularweightis82kDabutitwillrunbetween~90-140kDabecausethisproteinisglycosolated. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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