4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:分子类,蛋白类,抗体类,生化类试剂
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/MABT129 | Anti-VE-Cadherin Antibody (CD144), clone BV9/MABT129/100 µL
商品详细Millipore/MABT129 | Anti-VE-Cadherin Antibody (CD144), clone BV9/MABT129/100 µL
Millipore/MABT129 | Anti-VE-Cadherin Antibody (CD144), clone BV9/MABT129/100 µL
Millipore/MABT129 | Anti-VE-Cadherin Antibody (CD144), clone BV9/MABT129/100 µL
商品编号: MABT129
品牌: 密理博
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberMABT129
DescriptionAnti-VE-CadherinAntibody(CD144),cloneBV9
AlternateNames
  • Cadherin-5
  • 7B4antigen
  • Vascularendothelialcadherin
  • VE-cadherin
  • CD144
BackgroundInformationAlsoknownasCD144,humanVascularEndothelial(VE)-cadherinisacalcium-dependentadhesionmoleculestrictlylocatedatcelltocelljunctions.VE-cadherinispresentinalltypesofendothelium(veins,arteries,capillaryandlargevessels).Cadherinsarecalciumdependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.CadherinsarereportedtoplayanimportantroleinangiogeneisandinendothelialcellBIOLOGythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.ItassociateswithalphacateninformingalinktotheCytoskeleton.
ProductInformation
FormatPurified
Control
  • HUVECcells
PresentationPurifiedmousemonoclonalIgG2aκinbuffercontainingPBSwithout0.05%sodiumazide.
StorageandShippingInformation
StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
Applications
ApplicationThisVE-CadherinantibodyisvalidatedforuseinICC&EnzymeAssayforthedetectionoftheVE-Cadherinprotein.
KeyApplications
  • Immunocytochemistry
  • EnzymeAssays
ApplicationNotesActivityAssayAnalysis:ArepresentativelotfromanindependentlaboratoryincreasedendothelialpermeABIlity,inhibitedtheorganizationofvasclular-likestructures,andpreventedtheprotectiveeffectofVEGFagainstapoptosisinendothelialcells.
BiologicalInformation
ImmunogenRecombinantproteincorrespondingtotheextracellulardomainofhumanVE-Cadherin.
EpitopeExtracellulardomain.
CloneBV9
HostMouse
SpecificityThisantibodyrecognizestheextracellulardomainofVE-Cadherin.
IsotypeIgG2aκ
SpeciesReactivity
  • Human
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
EntrezGeneSummaryThisgeneisaclassicalcadherinfromthecadherinsuperfamilyandislocatedinasix-cadherinclusterinaregiononthelongarmofchromosome16thatisinvolvedinlossofheterozygosityeventsinbreastandprostatecancer.Theencodedproteinisacalcium-dependentcell-celladhesionglycoproteincomprisedoffiveextracellularcadherinrepeats,atransmembraneregionandahighlyconservedcytoplasmictail.Functioningasaclassiccadherinbyimpartingtocellstheabilitytoadhereinahomophilicmanner,theproteinmayplayanimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Analternativesplicevarianthasbeendescribedbutitsfulllengthsequencehasnotbeendetermined.
GeneSymbol
  • CDH5
PurificationMethodProteinGPurified
UniProtNumber
UniProtSummaryFUNCTION:Cadherinsarecalciumdependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.Thiscadherinmayplayaimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Itassociateswithalpha-cateninformingalinktothecytoskeleton.ActsinconcertwithKRIT1toestablishandmaintaincorrectendothelialcellpolarityandvascularlumen.TheseeffectsaremediatedbyrecruitmentandactivationoftheParpolaritycomplexandRAP1B.RequiredforactivationofPRKCZandforthelocalizationofphosphorylatedPRKCZ,PARD3,TIAM1andRAP1Btothecelljunction.

SUBUNITSTRUCTURE:Interactsviacadherin5domainwithPTPRB.InteractswithTRPC4.InteractswithKRIT1.

SUBCELLULARLOCATION:Celljunction.Cellmembrane;Single-passtypeImembraneprotein.Note:Foundatcell-cellboundariesandprobablyatcell-matrixboundaries.KRIT1andCDH5reciprocallyregulatetheirlocalizationtoendothelialcell-celljunctions.
MolecularWeight88kDacalculated
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。