4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:分子类,蛋白类,抗体类,生化类试剂
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/MABT117 | Anti-Endoglin (CD105) Antibody, clone 44G4/MABT117/100 µL
商品详细Millipore/MABT117 | Anti-Endoglin (CD105) Antibody, clone 44G4/MABT117/100 µL
Millipore/MABT117 | Anti-Endoglin (CD105) Antibody, clone 44G4/MABT117/100 µL
Millipore/MABT117 | Anti-Endoglin (CD105) Antibody, clone 44G4/MABT117/100 µL
商品编号: MABT117
品牌: 密理博
市场价: ¥6580.00
美元价: 3948.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberMABT117
DescriptionAnti-Endoglin(CD105)Antibody,clone44G4
AlternateNames
  • Endoglin
  • CD104
BackgroundInformationEndoglin(CD105)isahomodimericintegralmembraneglycoproteincomprisedofa95kDasubunit.EndoglinisacomponentoftheTGF-βreceptorsystemthatfunctionsasanancillaryreceptorinfluencingbindingoftheTransformingGrowthFactorbeta(TGF-β)familyofligandstosignalingreceptors.EndoglinbindstoTGF-β1andTGF-β3withhighaffinity,butdoesnotbindTGF-β2.Endoglinisexpressedbyvascularendothelialcellsandsyncytiotrophoblastsofplacentaandisweaklyexpressedbystromalfibroblasts.EndoglinisalsoexpressedbyU937cellsandbyactivatedmacrophages.Endoglinexpressionisup-regulatedonactivatedendotheliumintissuesundergoingangiogenesis,suchasintumors,orincasesofwoundhealingordermalinflammation.
ProductInformation
FormatPurified
Control
  • HUVECcells
PresentationPurifiedmousemonoclonalIgG1κinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
StorageandShippingInformation
StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
Applications
ApplicationAnti-Endoglin(CD105)Antibody,clone44G4isanantibodyagainstEndoglin(CD105)foruseinFC,IH&IP.
KeyApplications
  • FlowCytometry
  • Immunohistochemistry
  • Immunoprecipitation
ApplicationNotesImmunohistochemistryAnalysis:ArepresentativelotwasusedbyanindependentlaboratorytodetectEndoglininnormalhumanlymphnode,tonsil,spleenthrymus,liver,breast,lung,andkidneyspecimens(Gougos,A.,andLetarte,M.(1988).JImmunol.141(6):1925-1933).

ImmunoprecipitationAnalysis:ArepresentativelotwasusedbyanindependentlaboratorytoIPEndoglinfromHOON,NALM-6,3104,3161,HL-60,U-937,EM-3andKG-1acells(Gougos,A.,andLetarte,M.(1988).JImmunol.141(6):1925-1933).
BIOLOGicalInformation
ImmunogenWholeHOONPre-BLeukemicCells
Clone44G4
HostMouse
IsotypeIgG1κ
SpeciesReactivity
  • Human
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
EntrezGeneSummaryEndoglinisahomodimerictransmembraneglycoproteinhighlyexpressedbyendothelialcells.ItisacomponentofthetransforminggrowthfactorbetareceptorcomplexasitbindsTGFB1andTGFB3withhighaffinity.Mutationsintheendoglingeneproducehereditaryhemorrhagictelangiectasia.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene.
GeneSymbol
  • ENG
  • END
PurificationMethodProteinGPurified
UniProtNumber
UniProtSummaryFUNCTION:Majorglycoproteinofvascularendothelium.Mayplayacriticalroleinthebindingofendothelialcellstointegrinsand/orotherRGDreceptors.

SUBUNIT:Homodimerthatformsanheteromericcomplexwiththesignalingreceptorsfortransforminggrowthfactor-beta:TGF-betareceptorsIand/orII.ItisabletobindTGF-beta1,and3efficientlyandTGF-beta2lessefficiently.

SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
MolecularWeight71kDacalculated
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。