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Millipore/MABT117 | Anti-Endoglin (CD105) Antibody, clone 44G4/MABT117/100 µL
Millipore/MABT117 | Anti-Endoglin (CD105) Antibody, clone 44G4/MABT117/100 µL
市场价:
¥6580.00
美元价:
3948.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MABT117 |
| Description | Anti-Endoglin(CD105)Antibody,clone44G4 |
| AlternateNames |
|
| BackgroundInformation | Endoglin(CD105)isahomodimericintegralmembraneglycoproteincomprisedofa95kDasubunit.EndoglinisacomponentoftheTGF-βreceptorsystemthatfunctionsasanancillaryreceptorinfluencingbindingoftheTransformingGrowthFactorbeta(TGF-β)familyofligandstosignalingreceptors.EndoglinbindstoTGF-β1andTGF-β3withhighaffinity,butdoesnotbindTGF-β2.Endoglinisexpressedbyvascularendothelialcellsandsyncytiotrophoblastsofplacentaandisweaklyexpressedbystromalfibroblasts.EndoglinisalsoexpressedbyU937cellsandbyactivatedmacrophages.Endoglinexpressionisup-regulatedonactivatedendotheliumintissuesundergoingangiogenesis,suchasintumors,orincasesofwoundhealingordermalinflammation. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgG1κinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | WholeHOONPre-BLeukemicCells |
| Clone | 44G4 |
| Host | Mouse |
| Isotype | IgG1κ |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Endoglinisahomodimerictransmembraneglycoproteinhighlyexpressedbyendothelialcells.ItisacomponentofthetransforminggrowthfactorbetareceptorcomplexasitbindsTGFB1andTGFB3withhighaffinity.Mutationsintheendoglingeneproducehereditaryhemorrhagictelangiectasia.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene. |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Majorglycoproteinofvascularendothelium.Mayplayacriticalroleinthebindingofendothelialcellstointegrinsand/orotherRGDreceptors. SUBUNIT:Homodimerthatformsanheteromericcomplexwiththesignalingreceptorsfortransforminggrowthfactor-beta:TGF-betareceptorsIand/orII.ItisabletobindTGF-beta1,and3efficientlyandTGF-beta2lessefficiently. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. |
| MolecularWeight | 71kDacalculated |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。
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