微孔/MABS191 |抗磷酸-VEGFR2（Tyr1212）抗体，克隆12A10.1/MABS191/100µ；G
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MABS191 |
| Description | Anti-phospho-VEGFR2(Tyr1212)Antibody,clone12A10.1 |
| AlternateNames |
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| BackgroundInformation | KDR/Flk-1/VEGFR-2isaputativereceptorproteintyrosinekinaseexpressedinendothelialcellsofthedevelopingembryo.Vascularendothelialgrowthfactor(VEGF)andVEGFR2havebeenimplicatedasthekeyendothelialcell-specificfactorsignalingpathwayrequiredforpathologicalangiogenesis,includingtumorneovascularization.InhibitionoftheVEGFtyrosinekinasesignalingpathwayblocksnewbloodvesselformationingrowingtumors,leADIngtostasisorregressionoftumorgrowth. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
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| Presentation | PurifiedmousemonoclonalIgMκinbuffercontainingPBSwith0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. |
| Applications | |
|---|---|
| Application | ThisAnti-phospho-VEGFR2(Tyr1212)Antibody,clone12A10.1isvalidatedforuseinWBforthedetectionofphospho-VEGFR2(Tyr1212). |
| KeyApplications |
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| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugatedlinearpeptidecorrespondingtohumanVEGFR2phosphorylatedatTyr1212. |
| Epitope | PhosphorylatedTyr1212 |
| Clone | 12A10.1 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | ThisantibodyrecognizesVEGFR2phosphorylatedatTyr1212. |
| Isotype | IgMκ |
| SpeciesReactivity |
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| SpeciesReactivityNote | DemonstratedtoreactwithPorcine.PredictedtoreactwithHumanbasedon100%sequencehomology. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Vascularendothelialgrowthfactor(VEGF)isamajorgrowthfactorforendothelialcells.ThisgeneencodesoneofthetworeceptorsoftheVEGF.Thisreceptor,knownaskinaseinsertdomainreceptor,isatypeIIIreceptortyrosinekinase.ItfunctionsasthemainmediatorofVEGF-inducedendothelialproliferation,survival,migration,tubularmorphogenesisandsprouting.Thesignallingandtraffickingofthisreceptorareregulatedbymultiplefactors,includingRabGTPase,P2Ypurinenucleotidereceptor,integrinalphaVbeta3,T-cellproteintyrosinephosphatase,etc..Mutationsofthisgeneareimplicatedininfantilecapillaryhemangiomas. |
| GeneSymbol |
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| Modifications |
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| PurificationMethod | Purifiedionexchangechromatography |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Tyrosine-proteinkinasethatactsasacell-surfacereceptorforVEGFA,VEGFCandVEGFD.Playsanessentialroleintheregulationofangiogenesis,vasculardevelopment,vascularpermeABIlity,andembryonichaematopoiesis.Promotesproliferation,survival,migrationanddifferentiationofendothelialcells.PromotesreorganizationoftheactinCytoskeleton.Isoformslackingatransmembranedomain,suchasisoform2andisoform3,mayfunctionasdecoyreceptorsforVEGFA,VEGFCand/orVEGFD.Isoform2playsanimportantroleasnegativeregulatorofVEGFA-andVEGFC-mediatedlymphangiogenesisbylimitingtheamountoffreeVEGFAand/orVEGFCandpreventingtheirbindingtoFLT4.ModulatesFLT1andFLT4signalingbyformingheterodimers.Bindingofvasculargrowthfactorstoisoform1leadstotheactivationofseveralsignalingcascades.ActivationofPLCG1leadstotheproductionofthecellularsignalingmoleculesdiacylglycerolandinositol-1,4,5-trisphosphateandtheactivationofproteinkinaseC.MediatesactivationofMAPK1/ERK2,MAPK3/ERK1andtheMAPkinasesignalingpathway,aswellasoftheAKT1signalingpathway.MediatesphosphorylationofPIK3R1,theregulatorysubunitofphosphatidylinositol3-kinase,reorganizationoftheactincytoskeletonandactivationofPTK2/FAK1.RequiredforVEGFA-mediatedinductionofNOS2andNOS3,leadingtotheproductionofthesignalingmoleculenitricoxide(NO)byendothelialcells.PhosphorylatesPLCG1.PromotesphosphorylationofFYN,NCK1,NOS3,PIK3R1,PTK2/FAKandSRC. CATALYTICACTIVITY:ATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate. ENZYMEREGULATION:Presentinaninactiveconformationintheabsenceofboundligand.BindingofVEGFA,VEGFCorVEGFDleadstodimerizationandactivationbyautophosphorylationontyrosineresidues.InhibitedbythesmallmoleculePTKinhibitorSU5614((3Z)-5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one). SUBUNITSTRUCTURE:InteractswithMYOF.InteractswithVEGFA,VEGFCandVEGFD.MonomerintheabsenceofboundVEGFA,VEGFCorVEGFD.HomodimerinthepresenceofbounddimericVEGFA,VEGFCorVEGFD.CanalsoformheterodimerswithFLT1andFLT4.Interacts(tyrosinephosphorylated)withFYN,NCK1,PLCG1andSHB.InteractswithHIV-1Tat.InteractswithCBL.InteractswithSH2D2A/TSADandGRB2. SUBCELLULARLOCATION:Isoform1:Cellmembrane;Single-passtypeImembraneprotein.Cytoplasm.Nucleus.Cytoplasmicvesicle.Earlyendosome.Note:Detectedoncaveolae-enrichedlipidraftsatthecellsurface.Isrecycledfromtheplasmamembranetoendosomesandbackagain.PhosphorylationtriggeredbyVEGFAbindingpromotesinternalizationandsubsequentdegradation.VEGFAbindingtriggersinternalizationandtranslocationtothenucleus.Isoforms2and3aresecreted. TISSUESPECIFICITY:Detectedincornea(atproteinlevel).Widelyexpressed. |
| MolecularWeight | ~230kDaobserved |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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