Millipore/MAB4092 |抗P-选择素糖蛋白配体-1抗体，克隆KPL-1/MAB4092/100µ；G
市场价：
¥5540.00
美元价：
3324.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB4092 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-P-SelectinGlycoproteinLigand-1Antibody,cloneKPL-1 |
| AlternateNames |
|
| BackgroundInformation | InteractionsbetweenP-selectinandP-selectinglycoproteinligand-1(PSGL-1)mediatetheearliest“rolling”ofleukocytesonthelumenalsurfaceofendothelialcellsatsitesofinflammation.Todate,theprimaryroleofPSGL-1inmediatingtheinteractionbetweenneutrophilsandP-selectinhasbeenwelldocumented.MAB4092completelyblocksrecognitionofPSGL-1byeitherP-selectinorbyL-selectin,butdoesnotaffectleukocyterecognitionofE-selectin.TwocolorflowcytometryofnormalleukocyteshasdemonstratedthatPSGL-1isexpressedonessentiallyallbloodneutrophils,NKcells,bloodcells,Tcells,andmonocytes,butPSGL-1stainsBcellsatsignificantlylowerlevelsthanothercelltypes.VariationintyrosinesulfationduringBcelldifferentiationmayaffectthestABIlityofBcellstointeractwithP-andL-selectin.{Snapp,KRetal1998}. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | PurifiedImmunoglobulin.Liquidin0.02MPBwith0.25MNaCl,pH7.6,0.1%SodiumAzide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat2-8°Cinundilutedaliquotsupto12months. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | TheantibodyepitopewasmappedtoasitewithinaconsensustyrosinesulfationmotifofPSGL-1,previouslyshowntobeessentialforinteractionwithP-selectin(andnowshowntobeessentialforrecognitionofPSGL-1byL-selectin). |
| Clone | KPL-1 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | P-selectinglycoproteinligand-1(PSGL-1).TheantibodyepitopewasmappedtoasitewithinaconsensustyrosinesulfationmotifofPSGL-1,previouslyshowntobeessentialforinteractionwithP-selectin(andnowshowntobeessentialforrecognitionofPSGL-1byL-selectin).{SnappKRetal.1998}.ThebindingofKPL-1tohumanPSGL-1onHL-60cellsdoesnotrequiresulfation{Thatte,Aetal2002}. |
| Isotype | IgG1κ |
| SpeciesReactivity |
|
| SpeciesReactivityNote | KnownnottoreactwithRat,Bovine,Pig,andEquinePSGL-1{Snapp,KRetal1998;Baisse,Betal2007}. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | SELPLGisthehighaffinitycounter-receptorforP-selectinonmyeloidcellsandstimulatedTlymphocytes.Assuch,itplaysacriticalroleinthetetheringofthesecellstoactivatedplateletsorendotheliaexpressingP-selectin.TheorganizationoftheSELPGgenecloselyresemblesthatofCD43andthehumanplateletglycoproteinGpIb-alphabothofwhichhaveanintroninthe5-prime-noncodingregion,alongsecondexoncontainingthecompletecodingregion,andTATA-lesspromoters. |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q14242#BindstoP-,E-andL-selectins.Thecalcium-dependenthighaffinityinteractionwithP-selectinmediatesthetetheringandrollingofneutrophilsandT-lymphocytesonendothelialcells. SIZE:412aminoacids;43201Da SUBUNIT:Homodimer;disulfide-linked. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Expressedonneutrophils,monocytesandmostlymphocytes. PTM:Displayscomplex,sialylatedandfucosylatedO-linkedoligosaccharides,atleastsomeofwhichappeartocontainpoly-N-acetyllactosaminewithvaryingdegreesofsubstitution.AlsoN-glycosylated.&SulfatedintheN-terminalregion;sulfationisnecessaryforP-selectinbinding. |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
联络我们
