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Millipore/MAB3442 | Anti-von Willebrand Factor Antibody, clone 21-43/MAB3442/500 µL
Millipore/MAB3442 | Anti-von Willebrand Factor Antibody, clone 21-43/MAB3442/500 µL
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美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB3442 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-vonWillebrandFactorAntibody,clone21-43 |
| AlternateNames |
|
| BackgroundInformation | vonWillebrandFactorissynthesizedbyendothelialcells,causingadhesionofplateletstoinjuredvesselwallsandfunctionsasacarrierandstABIlizerforcoagulationofFactorVIII.ItisoneofthemostwidelyusedendothelialcellMarkersforstudyingangiogenesis/neovascularization. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgG1inbuffercontaining0.5mLphosphatebufferedsaline,pH7.4containing0.1%sodiumazideand0.2%bovineserumalbumin,diluted50%v/vwithglycerol. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor6monthsat2-8ºCfromdateofreceipt. Forprolongedperiods,storeat-15ºCto-20ºC.Atthistemperaturetheglycerolsolutionwillnotfreeze. |
| Applications | |
|---|---|
| Application | Anti-vonWillebrandFactorAntibody,clone21-43isanantibodyagainstvonWillebrandFactorforuseinELISA,IC,IF,IH,IH(P)&WB. |
| KeyApplications |
|
| ApplicationNotes | Apreviouslotoftheantibodywasusedfor:IH,IH(P)IC,ELISA. DetectingcarrierstatusandtodistinguishheterogeneityofhaemophiliaandvonWillebrand"sdiseasepatients. QuanitifyingthelevelsofvonWillebrandFactorinplasmabysandwichimmunoassay(Francis,1984,1985;Exner,1984).ImprovingpurificationofFactorVIII. Identifyingavarietyofvasculartumourssuchashaemangiomas,haemangiosarcomasandKaposi"ssarcoma. Theantibodyissuitableforusewithfrozenandformalinfixedtissuesections. Indirectimmunoperoxidasestaining-thefinaldilutionwilldependontheassayconditionsanddetectionsystememployed.However,adilutionofatleast1:50willbeapplicabletomostcommonlyusedsystems. Theantibodymaybeusedfor: -DetectingcarrierstatusandtodistinguishheterogeneityofhaemophiliaandvonWillebrand"sdiseasepatients. -QuanitifyingthelevelsofvonWillebrandFactorinplasmabysandwichimmunoassay(Francis,1984,1985;Exner,1984). -ImprovingpurificationofFactorVIII. -Identifyingavarietyofvasculartumourssuchashaemangiomas,haemangiosarcomasandKaposi"ssarcoma. Theantibodyissuitableforusewithfrozenandformalinfixedtissuesections. SUGGESTEDUSAGE Indirectimmunoperoxidasestaining-thefinaldilutionwilldependontheassayconditionsanddetectionsystememployed.However,adilutionofatleast1:50willbeapplicabletomostcommonlyusedsystems. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | PurifiedHumanFactorVIIIcomplex |
| Clone | 21-43 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | ThisantibodyreactsstronglywithhumanvonWillebrandFactororFactorVIIIRelatedAntigeninbothplasma,usingRIAorELISA,andintissuesbyimmunofluorescenceorimmunoperoxidasestaining.pI:6.55 |
| Isotype | IgG1 |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theglycoproteinencodedbythisgenefunctionsasbothanantihemophilicfactorcarrierandaplatelet-vesselwallmediatorinthebloodcoagulationsystem.Itiscrucialtothehemostasisprocess.MutationsinthisgeneordeficienciesinthisproteinresultinvonWillebrand"sdisease.Anunprocessedpseudogenehasbeenfoundonchromosome22. |
| GeneSymbol |
|
| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| UniProtSummary | SUBUNIT:Multimeric.InteractswithF8. |
| MolecularWeight | 310kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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