Millipore/07-1431 | Anti-Tie-2 Antibody, NT/07-1431/50 µg
市场价：
¥5740.00
美元价：
3444.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 07-1431 |
| Replaces | AB3126 |
| Description | Anti-Tie-2Antibody,NT |
| AlternateNames |
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| BackgroundInformation | Tie-2isamemberofthetyrosineproteinkinasefamily,isatransmembranereceptorforangiopoietin1,andmayrepresentoneoftheearliestMarkersforcelllineagewithinmammalianendothelialcells.Itsexpressionisalmostonlyfoundinhuman,mouseandratendothelialcellsandangioblasts.Mostlikely,Tie-2regulatesthedifferentiation,properdispersal,andproliferationofthesecellsduringangiogenesis.MutationsinTEKareacauseofVMCMordominantlyinheritedvenousmalformationswhicharecharacterizedbyserpiginious,dilatedveins.Tie-2canbefoundinplacentaandlungtissue.Lowerlevelsoftheproteincanalsobefoundinkidney,umbilicalveinendothelialcells,andbrain. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | Affinitypurifiedimmunoglobulin.Liquidin100mMTris,pH7.5,containing0.2%BSAand0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cinundilutedaliquotsforupto12monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles. |
| Applications | |
|---|---|
| Application | ThisAnti-Tie-2Antibody,N-terminusisvalidatedforuseinWBforthedetectionofTie-2. |
| KeyApplications |
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| BIOLOGicalInformation | |
|---|---|
| Immunogen | 18aminoacidpeptidesequencewithintheextracellular,N-terminusofhumanTie-2 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | RecognizeshumanTunicainternalendothelialcellkinase(TIE-2),alsodescribedasAngiopoietin-1receptor,p140TEK,ortyrosineproteinkinasereceptor.Thepeptidesequenceusedasimmunogenis100%conservedinhuman,rat,mouse,and94%inbovine. |
| SpeciesReactivity |
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| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
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| PurificationMethod | AffinityPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Thisproteinisaproteintyrosine-kinasetransmembranereceptorforangiopoietin1.Itmayconstitutetheearliestmammalianendothelialcelllineagemarker.Probablyregulatesendothelialcellproliferation,differentiationandguidestheproperpatterningofendothelialcellsduringbloodvesselformation. CATALYTICACTIVITY:ATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate. SUBUNITSTRUCTURE:InteractswithPTPRB. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:PredominantlyexpressedinendothelialcellsandtheirProgenitors,theangioblasts.Hasbeendirectlyfoundinplacentaandlung,withalowerlevelinumbilicalveinendothelialcells,brainandkidney. PTM:Phosphorylated.PhosphorylationisinducedbyANGPT1andANGPT2.ANGPT1-inducedphosphorylationisimpairedduringhypoxia.DephosphorylatedbyPTPRB. INVOLVEMENTINDISEASE:DefectsinTEKareacauseofdominantlyinheritedvenousmalformations(VMCM)[MIM:600195];anerrorofvascularmorphogenesischaracterizedbydilated,serpiginouschannels. SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Tiesubfamily. Contains3EGF-likedomains. Contains3fibronectintype-IIIdomains. Contains2Ig-likeC2-type(immunoglobulin-like)domains. Contains1proteinkinasedomain. |
| MolecularWeight | Approx.126kDa |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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