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Millipore/MAB1149 | Anti-Tie-2 Antibody, extracellular, clone 4G8HE/MAB1149/100 µg
Millipore/MAB1149 | Anti-Tie-2 Antibody, extracellular, clone 4G8HE/MAB1149/100 µg
市场价：
¥6580.00
美元价：
3948.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB1149 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-Tie-2Antibody,extracellular,clone4G8HE |
| Overview | Purity:Greaterthan95%bySDS-PAGE.0.22micronsterilefiltered. |
| AlternateNames |
|
| BackgroundInformation | Tie-2isanendothelial-specificreceptortyrosinekinaseandareceptorforangiopoietin1.ItisatypeImembraneproteinthatisexpressedpredominantlyintheendotheliumofactivelygrowingbloodvesselsandmayrepresenttheearliestmammalianendothelialcelllineageMarker.Tie-2islikelyinvolvedintheregulationofendothelialcellproliferationanddifferentiationandmaydirectthespecialorientationofendothelialcellsduringtheformationofbloodvessels. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | ImmunoglobulinpurifiedbyproteinGaffinitychromatography.LiquidinPBS,pH7.4,containing0.05%Bronidoxasapreservative. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainrefrigeratedat2-8°Cinundilutedaliquotsforupto12months. |
| Applications | |
|---|---|
| Application | Anti-Tie-2Antibody,extracellular,clone4G8HEdetectslevelofTie-2&hasbeenpublished&validatedforuseinELISA,FC&WB. |
| KeyApplications |
|
| ApplicationNotes | Westernblot:10μg/mL.Recognizesabandmigratingatapproximately140kDacorrespondingtomouseTie-2. FACS:10μg/mL ELISA Optimalworkingdilutionsmustbedeterminedbyenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | TheextracellulardomainofmouseTie-2receptor. |
| Epitope | extracellular |
| Clone | 4G8HE |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rat |
| Specificity | RecognizesmouseTie-2Receptor. |
| Isotype | IgG1 |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | TheTEKreceptortyrosinekinaseisexpressedalmostexclusivelyinendothelialcellsinmice,rats,andhumans.Thisreceptorpossessesauniqueextracellulardomaincontaining2immunoglobulin-likeloopsseparatedby3epidermalgrowthfactor-likerepeatsthatareconnectedto3fibronectintypeIII-likerepeats.Theligandforthereceptorisangiopoietin-1.DefectsinTEKareassociatedwithinheritedvenousmalformations;theTEKsignalingpathwayappearstobecriticalforendothelialcell-smoothmusclecellcommunicationinvenousmorphogenesis.TEKiscloselyrelatedtotheTIEreceptortyrosinekinase. |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q02763#Thisproteinisaproteintyrosine-kinasetransmembranereceptorforangiopoietin1.Itmayconstitutetheearliestmammalianendothelialcelllineagemarker.Probablyregulatesendothelialcellproliferation,differentiationandguidestheproperpatterningofendothelialcellsduringbloodvesselformation. SIZE:1124aminoacids;125811Da SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:PredominantlyexpressedinendothelialcellsandtheirProgenitors,theangioblasts.Hasbeendirectlyfoundinplacentaandlung,withalowerlevelinumbilicalveinendothelialcells,brainandkidney. DISEASE:SwissProt:Q02763#DefectsinTEKareacauseofdominantlyinheritedvenousmalformations(VMCM)[MIM:600195];anerrorofvascularmorphogenesischaracterizedbydilated,serpiginouschannels. SIMILARITY:SwissProt:Q02763##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Tiesubfamily.&Contains3EGF-likedomains.&Contains3fibronectintype-IIIdomains.&Contains2Ig-likeC2-type(immunoglobulin-like)domains.&Contains1proteinkinasedomain. |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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