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Millipore/FCMAB404PE | Milli-Mark® Anti-Tie2/TEK-PE Antibody, clone Ab33/FCMAB404PE/100 tests
Millipore/FCMAB404PE | Milli-Mark® Anti-Tie2/TEK-PE Antibody, clone Ab33/FCMAB404PE/100 tests
商品编号：
FCMAB404PE
品牌：
密理博
市场价：
¥5340.00
美元价：
3204.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | FCMAB404PE |
| TradeName |
|
| Description | Milli-Mark®Anti-Tie2/TEK-PEAntibody,cloneAb33 |
| AlternateNames |
|
| BackgroundInformation | TIE2(tyrosinekinasewithIgandEGFhomologydomains2)isexpressedalmostexclusivelyinendothelialcellsinmice,ratsandhumans.Thisreceptorpossessesauniqueextracellulardomaincontainingtwoimmunoglobulin-likeloopsseparatedbythreeepidermalgrowthfactor-likerepeatsthatareconnectedtothreefibronectintypeIII-likerepeats.TheligandforthereceptorisAngiopoietin1.DefectsinTIE2areassociatedwithinheritedvenousmalformations;theTIE2signalingpathwayappearstobecriticalforendothelialcell-smoothmusclecellcommunicationinvenousmorphogenesis. |
| ProductInformation | |
|---|---|
| Format | Phycoerythrin |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgG1kconjugatedtoPEinPBSwith0.1%sodiumazideand15mg/mLBSA. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainrefrigeratedat2-8°Cprotectedfromlightinundilutedaliquotsforupto6monthsfromdateofreceipt. |
| Applications | |
|---|---|
| Application | Milli-MarkAnti-Tie2/TEK-PEAntibody,cloneAb33isanantibodyagainstTie2/TEKforuseinFC. |
| KeyApplications |
|
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Fusionproteincorrespondingtoresidues1-745ofhumanTie2/TEKwithaC-terminalHis6-tagpurifiedfrominfectedSF-9cells. |
| Clone | Ab33 |
| Host | Mouse |
| Specificity | AntibodyrecognizesHumanTie2/TEK. |
| Isotype | IgG1κ |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | TheTEKreceptortyrosinekinaseisexpressedalmostexclusivelyinendothelialcellsinmice,rats,andhumans.Thisreceptorpossessesauniqueextracellulardomaincontaining2immunoglobulin-likeloopsseparatedby3epidermalgrowthfactor-likerepeatsthatareconnectedto3fibronectintypeIII-likerepeats.Theligandforthereceptorisangiopoietin-1.DefectsinTEKareassociatedwithinheritedvenousmalformations;theTEKsignalingpathwayappearstobecriticalforendothelialcell-smoothmusclecellcommunicationinvenousmorphogenesis.TEKiscloselyrelatedtotheTIEreceptortyrosinekinase. |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q02763#Thisproteinisaproteintyrosine-kinasetransmembranereceptorforangiopoietin1.ItmayconstitutetheearliestmammalianendothelialcelllineageMarker.Probablyregulatesendothelialcellproliferation,differentiationandguidestheproperpatterningofendothelialcellsduringbloodvesselformation. SIZE:1124aminoacids;125811Da SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:PredominantlyexpressedinendothelialcellsandtheirProgenitors,theangioblasts.Hasbeendirectlyfoundinplacentaandlung,withalowerlevelinumbilicalveinendothelialcells,brainandkidney. DISEASE:SwissProt:Q02763#DefectsinTEKareacauseofdominantlyinheritedvenousmalformations(VMCM)[MIM:600195];anerrorofvascularmorphogenesischaracterizedbydilated,serpiginouschannels. SIMILARITY:SwissProt:Q02763##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Tiesubfamily.&Contains3EGF-likedomains.&Contains3fibronectintype-IIIdomains.&Contains2Ig-likeC2-type(immunoglobulin-like)domains.&Contains1proteinkinasedomain. |
| MolecularWeight | 126kDaCalculated |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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