密理博/09-407 |抗磷酸-TIE2/TEK（Tyr992）抗体/09-407/100µ；L
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 09-407 |
| BrandFamily | Upstate |
| TradeName |
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| Description | Anti-phospho-TIE2/TEK(Tyr992)Antibody |
| AlternateNames |
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| BackgroundInformation | TIE2(TEK,tyrosinekinasewithIgandEGFhomologydomains2),areceptortyrosinekinase(RTK),isexpressedalmostexclusivelyinendothelialcellsandprimitivehematopoieticstemcellsinmice,ratsandhumans.Thisreceptorpossessesauniqueextracellulardomaincontainingtwoimmunoglobulin-likeloopsseparatedbythreeepidermalgrowthfactor-likerepeatsthatareconnectedtothreefibronectintypeIII-likerepeats.TheligandforthereceptorisAngiopoietin1(Ang-1),whichcancauseDok-R/Dok-2toassociatewithTek,resultingintyrosinephosphorylationofDok-RandthesubsequentrecruitmentofNckandthep21-activatingkinase(Pak/Pak1)totheactivatedreceptor.DefectsinTIE2areassociatedwithinheritedvenousmalformations.TheTIE2signalingpathwayappearstobecriticalforendothelialcell-smoothmusclecellcommunicationinvenousmorphogenesis. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | AffinitypurifiedrabbitpolyclonalIgGinstoragebuffercontainingPBSwith0.05%sodiumazidein50%glycerol. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20°Cfromdateofreceipt. HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. |
| Applications | |
|---|---|
| Application | Anti-phospho-TIE2/TEK(Tyr992)Antibodyisanantibodyagainstphospho-TIE2/TEK(Tyr992)foruseinIH,IP&WB. |
| KeyApplications |
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| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptideencompassingandincludingphosphorylatedTyr992ofhumanTIE2. |
| Host | Rabbit |
| Specificity | RecognizesTIE2/TEKphosphorylatedonTyr992. |
| Isotype | IgG |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Mouseandratexpectedtoreactbasedon100%homologyofimmunogen. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | TheTEKreceptortyrosinekinaseisexpressedalmostexclusivelyinendothelialcellsinmice,rats,andhumans.Thisreceptorpossessesauniqueextracellulardomaincontaining2immunoglobulin-likeloopsseparatedby3epidermalgrowthfactor-likerepeatsthatareconnectedto3fibronectintypeIII-likerepeats.Theligandforthereceptorisangiopoietin-1.DefectsinTEKareassociatedwithinheritedvenousmalformations;theTEKsignalingpathwayappearstobecriticalforendothelialcell-smoothmusclecellcommunicationinvenousmorphogenesis.TEKiscloselyrelatedtotheTIEreceptortyrosinekinase. |
| GeneSymbol |
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| Modifications |
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| PurificationMethod | Doubleaffinitypurificationoverbothnon-phospho-peptidecolumnfollowedbyphopshorylatedpeptidecolumn. |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q02763#Thisproteinisaproteintyrosine-kinasetransmembranereceptorforangiopoietin1.ItmayconstitutetheearliestmammalianendothelialcelllineageMarker.Probablyregulatesendothelialcellproliferation,differentiationandguidestheproperpatterningofendothelialcellsduringbloodvesselformation. SIZE:1124aminoacids;125811Da SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:PredominantlyexpressedinendothelialcellsandtheirProgenitors,theangioblasts.Hasbeendirectlyfoundinplacentaandlung,withalowerlevelinumbilicalveinendothelialcells,brainandkidney. DISEASE:SwissProt:Q02763#DefectsinTEKareacauseofdominantlyinheritedvenousmalformations(VMCM)[MIM:600195];anerrorofvascularmorphogenesischaracterizedbydilated,serpiginouschannels. SIMILARITY:SwissProt:Q02763##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Tiesubfamily.&Contains3EGF-likedomains.&Contains3fibronectintype-IIIdomains.&Contains2Ig-likeC2-type(immunoglobulin-like)domains.&Contains1proteinkinasedomain. |
| MolecularWeight | 145kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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