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当前位置: 首页 > 产品中心 > Sandwich_method_ELISA > Millipore/14-627 | EGFR (L861Q) Protein, active, 10 µg/14-627/10 µg
商品详细Millipore/14-627 | EGFR (L861Q) Protein, active, 10 µg/14-627/10 µg
Millipore/14-627 | EGFR (L861Q) Protein, active, 10 µg/14-627/10 µg
Millipore/14-627 | EGFR (L861Q) Protein, active, 10 µg/14-627/10 µg
商品编号: 14-627
品牌: 密理博
市场价: ¥6360.00
美元价: 3816.00
产地: 美国(厂家直采)
公司:
产品分类: 夹心法ELISA
公司分类: Sandwich_method_ELISA
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumber14-627
BrandFamilyUpstate
TradeName
  • Upstate
DescriptionEGFR(L861Q)Protein,active,10µg
OverviewN-terminalGST-tagged,recombinanthumanEGFReceptor,aminoacids696-endcontainingthemutationL861Q
ProductInformation
StorageandShippingInformation
StorageConditions6monthsat-70°C
Applications
ApplicationActive,N-terminalGST-tagged,recombinanthumanEGFReceptor,aminoacids696-endcontainingthemutationL861Q,foruseinEnzymeAssays.
KeyApplications
  • EnzymeAssays
BIOLOGicalInformation
SourcebaculovirusinSf21insectcells
SpecificActivityForSpecificActivitydata,refertotheCertificateofAnalysisforindividuallotsofthisenzyme.
EntrezGeneNumber
GeneSymbol
  • EGFR
  • ERBB1
  • ERBB
  • mENA
ProteinTargetEGFR
PurificationMethodGlutathione-agarose
TargetSub-FamilyTK
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P00533#Isoform2/truncatedisoformmayactasanantagoNIST.
SIZE:1210aminoacids;134277Da
SUBUNIT:BindsRIPK1.CBLinteractswiththeautophosphorylatedC-terminaltailoftheEGFreceptor.PartofacomplexwithERBB2andeitherPIK3C2AorPIK3C2B.TheautophosphorylatedforminteractswithPIK3C2B,maybeindirectly.InteractswithPELP1.
SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.&Isoform2:Secreted.
TISSUESPECIFICITY:Expressedinplacenta.Isoform2isalsoexpressedinovariancancers.
PTM:PhosphorylationofSer-695ispartialandoccursonlyifThr-693isphosphorylated.&MonoubiquitinatedandpolyubiquitinateduponEGFstimulation;whichdoesnotaffecttyrosinekinaseactivityorsignalingcapacitybutmayplayaroleinlysosomaltargeting.Polyubiquitinlinkageismainlythrough"Lys-63",butlinkagethrough"Lys-48","Lys-11"and"Lys-29"alsooccur.DISEASE:SwissProt:P00533#DefectsinEGFRareassociatedwithlungcancer[MIM:211980].
SIMILARITY:SwissProt:P00533##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.EGFreceptorsubfamily.&Contains1proteinkinasedomain.
MISCELLANEOUS:BindingofEGFtothereceptorleadstodimerization,internalizationoftheEGF-receptorcomplex,inductionofthetyrosinekinaseactivity,stimulationofcellDNAsynthesis,andcellproliferation.
MolecularWeight85.8kDa
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。