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Millipore/FCMAB129CP | Milli-Mark Anti-EGFR-PerCP Antibody, clone LA22/FCMAB129CP/100 tests
Millipore/FCMAB129CP | Milli-Mark Anti-EGFR-PerCP Antibody, clone LA22/FCMAB129CP/100 tests
商品编号：
FCMAB129CP
品牌：
密理博
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | FCMAB129CP |
| TradeName |
|
| Description | Milli-MarkAnti-EGFR-PerCPAntibody,cloneLA22 |
| AlternateNames |
|
| BackgroundInformation | Proteinkinasesareenzymesthattransferaphosphategroupfromaphosphatedonorontoanacceptoraminoacidinasubstrateprotein.Bythisbasicmechanism,proteinkinasesmediatemostofthesignaltransductionineukaryoticcells,regulatingcellularmetabolism,transcription,cellcycleprogression,cytoskeletalrearrangementandcellmovement,apoptosis,anddifferentiation.Theproteinkinasefamilyisoneofthelargestfamiliesofproteinsineukaryotes,classifiedin8majorgroupsbasedonsequencecomparisonoftheirtyrosine(PTK)orserine/threonine(STK)kinasecatalyticdomains.EpidermalGrowthfactorreceptor(EGFR)istheprototypememberofthetype1receptortyrosinekinases.EGFRoverexpressionintumorsindicatespoorprognosisandisobservedintumorsoftheheadandneck,brain,bladder,stomach,breast,lung,endometrium,cervix,vulva,ovary,esophagus,stomachandinsquamouscellcarcinoma. |
| ProductInformation | |
|---|---|
| Format | PerCP |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgG2aconjugatedtoPerCPinPBSwith0.1%sodiumazideand15mg/mLBSA. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainrefrigeratedat2-8oCprotectedfromlightinundilutedaliquotsforupto6monthsfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | A431membraneproteins |
| Epitope | Unknown |
| Clone | LA22 |
| Host | Mouse |
| Specificity | RecognizesthesequenceofAla351-Asp364ofhumanEGFreceptor,Mr180kDa,(basedonnumberingwithoutthesignalpeptide)(Wuetal.,1989). |
| Isotype | IgG2a |
| SpeciesReactivity |
|
| SpeciesReactivityNote | TestedandpassedonHuman.basedon100%sequencehomology. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgeneisatransmembraneglycoproteinthatisamemberoftheproteinkinasesuperfamily.Thisproteinisareceptorformembersoftheepidermalgrowthfactorfamily.EGFRisacellsurfaceproteinthatbindstoepidermalgrowthfactor.Bindingoftheproteintoaligandinducesreceptordimerizationandtyrosineautophosphorylationandleadstocellproliferation.Mutationsinthisgeneareassociatedwithlungcancer.[providedbyRefSeq]. |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P00533#Isoform2/truncatedisoformmayactasanantagoNIST. SIZE:1210aminoacids;134277Da SUBUNIT:BindsRIPK1.CBLinteractswiththeautophosphorylatedC-terminaltailoftheEGFreceptor.PartofacomplexwithERBB2andeitherPIK3C2AorPIK3C2B.TheautophosphorylatedforminteractswithPIK3C2B,maybeindirectly.InteractswithPELP1. SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.&Isoform2:Secreted. TISSUESPECIFICITY:Expressedinplacenta.Isoform2isalsoexpressedinovariancancers. PTM:PhosphorylationofSer-695ispartialandoccursonlyifThr-693isphosphorylated.&MonoubiquitinatedandpolyubiquitinateduponEGFstimulation;whichdoesnotaffecttyrosinekinaseactivityorsignalingcapacitybutmayplayaroleinlysosomaltargeting.Polyubiquitinlinkageismainlythrough"Lys-63",butlinkagethrough"Lys-48","Lys-11"and"Lys-29"alsooccur.DISEASE:SwissProt:P00533#DefectsinEGFRareassociatedwithlungcancer[MIM:211980]. SIMILARITY:SwissProt:P00533##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.EGFreceptorsubfamily.&Contains1proteinkinasedomain. MISCELLANEOUS:BindingofEGFtothereceptorleadstodimerization,internalizationoftheEGF-receptorcomplex,inductionofthetyrosinekinaseactivity,stimulationofcellDNAsynthesis,andcellproliferation |
| MolecularWeight | 180kDaObserved |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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