当前位置:
首页
>
产品中心 >
Functional_antibody >
Millipore/16-244 |抗磷酸化EGFR(Tyr1173)抗体,克隆9H2,Alexa Fluor®488/16-244/25µ;G

Millipore/16-244 |抗磷酸化EGFR(Tyr1173)抗体,克隆9H2,Alexa Fluor®488/16-244/25µ;G
市场价:
¥5740.00
美元价:
3444.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description | |
---|---|
CatalogueNumber | 16-244 |
BrandFamily | Upstate |
TradeName |
|
Description | Anti-phospho-EGFR(Tyr1173)Antibody,clone9H2,AlexaFluor®488 |
ProductInformation | |
---|---|
Format | AlexaFluor®488 |
StorageandShippingInformation | |
---|---|
StorageConditions | 1yearat4°Cfromdateofshipment |
BIOLOGicalInformation | |
---|---|
Immunogen | KLH-conjugated,syntheticpeptidecontainingtheY1173motif(...NAE[pY1173]LRV...)ofthehumanEGFR |
Clone | 9H2 |
Host | Mouse |
Specificity | themotifNAE[pY]LRVcorrespondingtothemajorautophosphorylationsiteofthehumanEGFR |
Isotype | IgG1κ |
SpeciesReactivity |
|
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
GeneSymbol |
|
Modifications |
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P00533#Isoform2/truncatedisoformmayactasanantagoNIST. SIZE:1210aminoacids;134277Da SUBUNIT:BindsRIPK1.CBLinteractswiththeautophosphorylatedC-terminaltailoftheEGFreceptor.PartofacomplexwithERBB2andeitherPIK3C2AorPIK3C2B.TheautophosphorylatedforminteractswithPIK3C2B,maybeindirectly.InteractswithPELP1. SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.&Isoform2:Secreted. TISSUESPECIFICITY:Expressedinplacenta.Isoform2isalsoexpressedinovariancancers. PTM:PhosphorylationofSer-695ispartialandoccursonlyifThr-693isphosphorylated.&MonoubiquitinatedandpolyubiquitinateduponEGFstimulation;whichdoesnotaffecttyrosinekinaseactivityorsignalingcapacitybutmayplayaroleinlysosomaltargeting.Polyubiquitinlinkageismainlythrough"Lys-63",butlinkagethrough"Lys-48","Lys-11"and"Lys-29"alsooccur.DISEASE:SwissProt:P00533#DefectsinEGFRareassociatedwithlungcancer[MIM:211980]. SIMILARITY:SwissProt:P00533##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.EGFreceptorsubfamily.&Contains1proteinkinasedomain. MISCELLANEOUS:BindingofEGFtothereceptorleadstodimerization,internalizationoftheEGF-receptorcomplex,inductionofthetyrosinekinaseactivity,stimulationofcellDNAsynthesis,andcellproliferation. |
MolecularWeight | 175kDa |
PhysicochemicalInformation |
---|
Dimensions |
---|
MaterialsInformation |
---|
MaterialsInformation |
---|
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。
联络我们