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Millipore/05-1004 |抗磷酸化EGFR（Tyr1173）抗体，克隆3G3.2/05-1004/100µ；G
Millipore/05-1004 |抗磷酸化EGFR（Tyr1173）抗体，克隆3G3.2/05-1004/100µ；G
市场价：
¥5960.00
美元价：
3576.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 05-1004 |
| Description | Anti-phospho-EGFR(Tyr1173)Antibody,clone3G3.2 |
| AlternateNames |
|
| BackgroundInformation | Theepidermalgrowthfactorreceptor(EGFR;ErbB-1;HER1inhumans)isthecell-surfacereceptorformembersoftheepidermalgrowthfactorfamily(EGF-family)ofextracellularproteinligands.TheepidermalgrowthfactorreceptorisamemberoftheErbBfamilyofreceptors,asubfamilyoffourcloselyrelatedreceptortyrosinekinases:EGFR(ErbB-1),HER2/c-neu(ErbB-2),Her3(ErbB-3)andHer4(ErbB-4).MutationsaffectingEGFRexpressionoractivitycouldresultincancer.EGFR(epidermalgrowthfactorreceptor)existsonthecellsurfaceandisactivatedbybindingofitsspecificligands,includingepidermalgrowthfactorandtransforminggrowthfactorα(TGFα).EGFRdimerizationstimulatesitsintrinsicintracellularprotein-tyrosinekinaseactivity.Asaresult,autophosphorylationoffivetyrosine(Y)residuesintheC-terminaldomainofEGFRoccurs. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | Purifiedmouseascitescontaining0.1MTris-glycine,pH7.4,150mMNaCland0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainrefrigeratedat2-8°Cfor1yearfromdateofreceipt. |
| Applications | |
|---|---|
| Application | Detectphospho-EGFR(Tyr1173)usingthisAnti-phospho-EGFR(Tyr1173)Antibody,clone3G3.2validatedforuseinWB,FC,IH&IC. |
| KeyApplications |
|
| ApplicationNotes | FlowCytometryAnalysis:A431cellsstainedusing10ug/mLofanti-phospho-EGFR(Tyr1173). ImmunocytochemistryAnalysis:A1:500dilutionofthisantibody detectedanti-phospho-EGFR(Tyr1173)inEGFtreatedA431 lysates. ImmunohistochemistryAnalysis:A1:100dilutionofthisdetectedanti-phospho-EGFR(Tyr1173)inSEROusovariancancer. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugatedlinearpeptidecorrespondingtoresiduessurroundingTyr1173ofEGFR. |
| Epitope | PhosphorylatedTyr1173 |
| Clone | 3G3.2 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | ThisantibodyrecognizesphosphorylatedEGFR(Tyr1173). |
| Isotype | IgG1κ |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Proventoreactwithhuman. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgeneisatransmembraneglycoproteinthatisamemberoftheproteinkinasesuperfamily.Thisproteinisareceptorformembersoftheepidermalgrowthfactorfamily.EGFRisacellsurfaceproteinthatbindstoepidermalgrowthfactor.Bindingoftheproteintoaligandinducesreceptordimerizationandtyrosineautophosphorylationandleadstocellproliferation.Mutationsinthisgeneareassociatedwithlungcancer. |
| GeneSymbol |
|
| Modifications |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneproteinPotential. SEQUENCESIMILARITIES:Contains1C-typelectindomain. Contains1EGF-likedomain. |
| MolecularWeight | 175kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
|---|
| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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