密理博/05-947 |抗磷酸酪氨酸抗体，克隆PY20/05-947/1 mg
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 05-947 |
| Replaces | MAB3080 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-PhosphotyrosineAntibody,clonePY20 |
| BackgroundInformation | Tyrosinephosphorylationrepresentsamajormechanismfortheactivationofsignaltransductionpathwaysinresponsetogrowthfactors,hormonesandcytokines.Thereareapproximately100tyrosinekinasesthatarebothreceptortyrsosinekinasereceptorsforvariousgrowthfactorsandcytokines.Theextentanddurationoftyrosinephosphorylationaretightlyregulatedbythe107proteintyrosinephosphatases.Tyrosinephosphorylationoccursonresiduesoneitherotherkinases(Ser/ThrorTyr)oronsubstrates.Inthecaseofkinases,thisphosphorylationoftencausestheenzymetochangeactivationstatesand/oritcreatesbindingsitesforSH2domain.Mutationormisregulationofproteintyrosinekinasesisacauseorconsequenceofmanydiseasestates.Ithasbeenestimatedthat20%ofoncogenessofardescribedaretyrosinekinases.Withsuchclearlinksbetweenaberrantproteintyrosinekinaseactivityanddisease,itisnosurprisethatmuchoftheearlyeffortinkinasedrugdiscoverywasfocusedontheseenzymes. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | 0.1MTris-Glycine,0.15MNaCl,0.05%SodiumAzide,pH7.4.Liquidat2-8°C. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofrecipt. Formaximumrecoveryoftheproduct,centrifugetheoriginalvialpriortoremovingthecap.Iftheproducthasaccidentallybeenfrozenandthawed,spinitat13,000xgfor10minutesat2-8°C.Savethesupernatantforapplication. |
| Applications | |
|---|---|
| Application | Anti-PhosphotyrosineAntibody,clonePY20isanantibodyagainstPhosphotyrosineforuseinELISA,IP&WB. |
| KeyApplications |
|
| ApplicationNotes | Immunoprecipitation: Recommendedbyanindependentlaboratorytoimmunoprecipitatetyrosinephosphorylatedproteins. ELISA: Recommendedbyanindependentlaboratory. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Phosphotyrosineconjugatedtocarrierprotein. |
| Clone | PY20 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | Tyrosine-phosphorylatedproteinsfromallspecies. |
| Isotype | IgG2b |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Mostcommonvertebratespeciestested.Reactivitywithotherspecieshasnotbeenconfirmed. |
| AntibodyType | MonoclonalAntibody |
| Modifications |
|
| PurificationMethod | ProteinAPurfied |
| MolecularWeight | Dependentuponthemolecularweightofthetyrosinephosphorylatedproteinbeingdetected. |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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