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Millipore/14-507 | TrkB重组人蛋白,活性,10µg/14-507/10µ;gAlso有250µg尺寸可供选择--请致电

Millipore/14-507 | TrkB重组人蛋白,活性,10µg/14-507/10µ;gAlso有250µg尺寸可供选择--请致电
市场价:
¥50880.00
美元价:
30528.00
产品分类:
夹心法ELISA
公司分类:
Sandwich_method_ELISA
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description | |
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CatalogueNumber | 14-507 |
BrandFamily | Upstate |
TradeName |
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Description | TrkBRecombinantHumanProtein,Active,10µg |
Overview | N-terminalHis6tagged,recombinant,humanTrkB,aminoacids455-end |
ProductInformation |
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StorageandShippingInformation | |
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StorageConditions | 6monthsat-70°C |
Applications | |
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Application | Active,N-terminalHis6tagged,recombinant,humanTrkB,aminoacids455-end,foruseinKinaseAssays. |
KeyApplications |
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BIOLOGicalInformation | |
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Source | expressedinSf21cells |
SpecificActivity | ForSpecificActivitydata,refertotheCertificateofAnalysisforindividuallotsofthisenzyme. |
EntrezGeneNumber | |
EntrezGeneSummary | Thisgeneencodesamemberoftheneurotrophictyrosinereceptorkinase(NTRK)family.Thiskinaseisamembrane-boundreceptorthat,uponneurotrophinbinding,phosphorylatesitselfandmembersoftheMAPKpathway.Signallingthroughthiskinaseleadstocelldifferentiation.Mutationsinthisgenehavebeenassociatedwithobesityandmooddisorders.Alternatetranscriptionalsplicevariantsencodingdifferentisoformshavebeenfoundforthisgene. |
GeneSymbol |
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ProteinTarget | TrkB |
PurificationMethod | Ni2+/NTA-agarose |
TargetSub-Family | TK |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:Q16620#Receptorforbrain-derivedneurotrophicfactor(BDNF),neurotrophin-3andneurotrophin-4/5butnotnervegrowthfactor(NGF).Involvedinthedevelopmentand/ormaintenanceofthenervoussystem.Thisisatyrosine-proteinkinasereceptor.KnownsubstratesfortheTRKreceptorsareSHC1,PI-3kinase,andPLC-gamma-1. SIZE:822aminoacids;91999Da SUBUNIT:Existsinadynamicequilibriumbetweenmonomeric(lowaffinity)anddimeric(highaffinity)structures.BindsSH2B2.InteractswithSQSTM1(Bysimilarity). SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:IsoformTrkBiswidelyexpressed,mainlyinthenervoustissue.IntheCNS,expressionisobservedinthecerebralcortex,hippocampus,thalamus,choroidplexus,granularlayerofthecerebellum,brainstem,andspinalcord.Intheperipheralnervoussystem,itisexpressedinmanycranialganglia,theophtalmicnerve,thevestibularsystem,multiplefacialstructures,thesuBMAxillaryglands,anddorsalrootganglia.IsoformTrkB-T1isexpressedinmultipletissues,mainlyinbrain,pancreas,kidneyandheart.IsoformTrkB-T-Shcispredominantlyexpressedinbrain. PTM:Ligand-mediatedauto-phosphorylation. SIMILARITY:SwissProt:Q16620##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Insulinreceptorsubfamily.&Contains2Ig-likeC2-type(immunoglobulin-like)domains.&Contains2LRR(leucine-rich)repeats.&Contains1proteinkinasedomain. |
MolecularWeight | 42.9kDa |
PhysicochemicalInformation |
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Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。
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