Millipore/07-225 | Anti-TrkB Antibody/07-225/200 µg
市场价：
¥7180.00
美元价：
4308.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 07-225 |
| BrandFamily | Upstate |
| TradeName |
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| Description | Anti-TrkBAntibody |
| AlternateNames |
|
| BackgroundInformation | TheTrk(tropomyosin-receptor-kinase)proto-oncogenefamilyofreceptortyrosinekinasescontainsfourmembers,TrkA,TrkB,TrkC,andTrkE,whicharevariablyexpressedthroughoutthecentralandperipheralnervoussystems.TrkBisthehigh-affinitytothebindingbrain-derivedneurotrophicfactor(BDNF)receptorandneurotrophin-4/5NT-4/5).TrkBisautophosphorylatedonfivecytoplasmictyrosines.ThebindingofBDNFtoTrkBreceptorcausesmanyintercellularcascadestobeactivatedsuchaspromotingsurvivalofsensoryneuronsmainlythroughShcsite-independentpathways.ThesignalingactivityofthesereceptorsincludestheRas–MAPkinasepathway,andthePI3Kinasepathway.ThesereceptorsareresponsIBLeforresistancetoapoptosis,obesity,Alzheimer’sdisease,andmooddisorders. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
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| Presentation | Purifiedrabbitpolyclonalinbuffercontaining0.014Mphosphatebuffer,pH7.6,0.175MNaCl,0.07%sodiumazide,and30%glycerol. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt. |
| Applications | |
|---|---|
| Application | ThisAnti-TrkBAntibodyisvalidatedforuseinWBforthedetectionofTrkB. |
| KeyApplications |
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| BIOLOGicalInformation | |
|---|---|
| Immunogen | Theentireextracellulardomain(correspondingtoresidues1–429)oftheratTrkBreceptor,expressedinCOScells.Theimmunizingsequencehas97%identitywithmouseTrkBand88%identitywithhumanTrkB. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | RecognizesTrkB,Mr145kDa,aswellasanadditionalprotein,Mr90kDa,whichislikelyaTrkBdegradationproduct. |
| Isotype | IgG |
| SpeciesReactivity |
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| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Receptorforbrain-derivedneurotrophicfactor(BDNF)[RGD]. |
| GeneSymbol |
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| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q16620#Receptorforbrain-derivedneurotrophicfactor(BDNF),neurotrophin-3andneurotrophin-4/5butnotnervegrowthfactor(NGF).Involvedinthedevelopmentand/ormaintenanceofthenervoussystem.Thisisatyrosine-proteinkinasereceptor.KnownsubstratesfortheTRKreceptorsareSHC1,PI-3kinase,andPLC-gamma-1. SIZE:822aminoacids;91999Da SUBUNIT:Existsinadynamicequilibriumbetweenmonomeric(lowaffinity)anddimeric(highaffinity)structures.BindsSH2B2.InteractswithSQSTM1(Bysimilarity). SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:IsoformTrkBiswidelyexpressed,mainlyinthenervoustissue.IntheCNS,expressionisobservedinthecerebralcortex,hippocampus,thalamus,choroidplexus,granularlayerofthecerebellum,brainstem,andspinalcord.Intheperipheralnervoussystem,itisexpressedinmanycranialganglia,theophtalmicnerve,thevestibularsystem,multiplefacialstructures,thesuBMAxillaryglands,anddorsalrootganglia.IsoformTrkB-T1isexpressedinmultipletissues,mainlyinbrain,pancreas,kidneyandheart.IsoformTrkB-T-Shcispredominantlyexpressedinbrain. PTM:Ligand-mediatedauto-phosphorylation. SIMILARITY:SwissProt:Q16620##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Insulinreceptorsubfamily.&Contains2Ig-likeC2-type(immunoglobulin-like)domains.&Contains2LRR(leucine-rich)repeats.&Contains1proteinkinasedomain. |
| MolecularWeight | 145κDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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