Millipore/CBL431 |抗N-Myc抗体,克隆IA8/CBL431/100µ;G
市场价:
¥0.00
美元价:
0.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description | |
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CatalogueNumber | CBL431 |
Replaces | CBL437 |
BrandFamily | Chemicon® |
TradeName |
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Description | Anti-N-MycAntibody,cloneIA8 |
ProductInformation | |
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Format | Purified |
Presentation | Themonoclonalispresentedataconcentrationof100μg/1mlinphosphatebufferedsalinecontaining10mMsodiumazideand1mg/mlbovineserumalbumin.Werecommendthateachlaboratorydetermineanoptimumworkingtitreforuseinitsparticularapplication. |
StorageandShippingInformation | |
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StorageConditions | Forusewithin1monthofpurchasestoreat+4°C,forlongtermstoragealiquotantibodyintosmallvolumesandstoreat-20C. |
BIOLOGicalInformation | |
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Immunogen | HumanN-mycsequence334-343+Cys. |
Clone | IA8 |
Host | Mouse |
Specificity | Theantibodyreactswithamajorpeptide-blockablebandat62-64kDaonwesternblots. |
Isotype | IgG2b |
SpeciesReactivity |
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AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | ThisgeneisamemberoftheMYCfamilyandencodesaproteinwithabasichelix-loop-helix(bHLH)domain.ThisproteinislocatedinthenucleusandmustdimerizewithanotherbHLHproteininordertobindDNA.Amplificationofthisgeneisassociatedwithavarietyoftumors,mostnotablyneuroblastomas.[providedbyRefSeq]. |
GeneSymbol |
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UniProtNumber | |
UniProtSummary | FUNCTION:Mayfunctionasatranscriptionfactor. SIZE:464aminoacids;49561Da SUBUNIT:EfficientDNAbindingrequiresdimerizationwithanotherbHLHprotein.BindsDNAasanheterodimerwithMAX.InteractswithKDM5A,KDM5BandHUWE1. SUBCELLULARLOCATION:Nucleus. DEVELOPMENTALSTAGE:Expressedduringfetaldevelopment. DISEASE:AmplificationoftheN-MYCgeneisassociatedwithavarietyofhumantumors,mostfrequentlyneuroblastoma,wherethelevelofamplificationappearstoincreaseasthetumorprogresses. DefectsinMYCNarethecauseofFeingoldsyndrome;alsoknownasoculodigitoesophagoduodenalsyndrome(ODED).Feingoldsyndromeischaracterizedbyvariablecombinationsofesophagealandduodenalatresias,microcephaly,learningdisABIlityandlimbmalformations.Cardiacandrenalmalformations,vertebralanomalies,anddeafnesshavealsobeendescribed. DefectsinMYCNarethecauseofmicrocephalyanddigitalabnormalitieswithnormalintelligence. SIMILARITY:Contains1basichelix-loop-helix(bHLH)domain. |
PhysicochemicalInformation |
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Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。
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