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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/CBL431 |抗N-Myc抗体,克隆IA8/CBL431/100µ;G
商品详细Millipore/CBL431 |抗N-Myc抗体,克隆IA8/CBL431/100µ;G
Millipore/CBL431 |抗N-Myc抗体,克隆IA8/CBL431/100µ;G
Millipore/CBL431 |抗N-Myc抗体,克隆IA8/CBL431/100µ;G
商品编号: CBL431
品牌: 密理博
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberCBL431
ReplacesCBL437
BrandFamilyChemicon®
TradeName
  • Chemicon
DescriptionAnti-N-MycAntibody,cloneIA8
ProductInformation
FormatPurified
PresentationThemonoclonalispresentedataconcentrationof100μg/1mlinphosphatebufferedsalinecontaining10mMsodiumazideand1mg/mlbovineserumalbumin.Werecommendthateachlaboratorydetermineanoptimumworkingtitreforuseinitsparticularapplication.
StorageandShippingInformation
StorageConditionsForusewithin1monthofpurchasestoreat+4°C,forlongtermstoragealiquotantibodyintosmallvolumesandstoreat-20C.
Applications
ApplicationAnti-N-MycAntibody,cloneIA8isahighqualityMouseMonoclonalAntibodyforthedetectionofN-Myc&hasbeenvalidatedinWB&IHC.
KeyApplications
  • WesternBlotting
  • Immunohistochemistry
ApplicationNotesWesternblottingondetergentlysatesfromcellsexpressingN-myc.

ImmunohistochemicalstudiesofN-myconfrozensections.

Optimalworkingdilutionsmustbedeterminedbytheenduser.
BIOLOGicalInformation
ImmunogenHumanN-mycsequence334-343+Cys.
CloneIA8
HostMouse
SpecificityTheantibodyreactswithamajorpeptide-blockablebandat62-64kDaonwesternblots.
IsotypeIgG2b
SpeciesReactivity
  • Human
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
EntrezGeneSummaryThisgeneisamemberoftheMYCfamilyandencodesaproteinwithabasichelix-loop-helix(bHLH)domain.ThisproteinislocatedinthenucleusandmustdimerizewithanotherbHLHproteininordertobindDNA.Amplificationofthisgeneisassociatedwithavarietyoftumors,mostnotablyneuroblastomas.[providedbyRefSeq].
GeneSymbol
  • MYCN
  • NMYC
  • N-Myc
  • BHLHE37
UniProtNumber
UniProtSummaryFUNCTION:Mayfunctionasatranscriptionfactor.
SIZE:464aminoacids;49561Da
SUBUNIT:EfficientDNAbindingrequiresdimerizationwithanotherbHLHprotein.BindsDNAasanheterodimerwithMAX.InteractswithKDM5A,KDM5BandHUWE1.
SUBCELLULARLOCATION:Nucleus.
DEVELOPMENTALSTAGE:Expressedduringfetaldevelopment.
DISEASE:AmplificationoftheN-MYCgeneisassociatedwithavarietyofhumantumors,mostfrequentlyneuroblastoma,wherethelevelofamplificationappearstoincreaseasthetumorprogresses.
DefectsinMYCNarethecauseofFeingoldsyndrome;alsoknownasoculodigitoesophagoduodenalsyndrome(ODED).Feingoldsyndromeischaracterizedbyvariablecombinationsofesophagealandduodenalatresias,microcephaly,learningdisABIlityandlimbmalformations.Cardiacandrenalmalformations,vertebralanomalies,anddeafnesshavealsobeendescribed.
DefectsinMYCNarethecauseofmicrocephalyanddigitalabnormalitieswithnormalintelligence.
SIMILARITY:Contains1basichelix-loop-helix(bHLH)domain.
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。