Millipore/MAB8864 |抗c-myc抗体，克隆9E10.3/MAB8864/50µ；G
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB8864 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-c-mycAntibody,clone9E10.3 |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
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| Presentation | Liquidin10mMPBS,pH7.4,with0.2%BSAand0.09%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat2-8°Cforupto12months. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Asyntheticpeptide,correspondingtoaa408-439(AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA)fromC-terminusofhumanc-myc,coupledtoKLH. |
| Epitope | a.a.410-419 |
| Clone | 9E10.3 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | MAB8864recognizesanoncoproteinof64-67kDa,identifiedasc-myc.Itseptiopespansbetweenaa410-419(EQKLISEEDL)whichisaspecificportionofanalphahelicalregionofhumanc-mycprotein.MAB8864showsnocross-reactionwithv-myc.c-mycisinvolvedinthecontrolofcellproliferationanddifferentiationandisamplifiedand/oroverexpressedinavarietyoftumors. |
| Isotype | IgG1κ |
| SpeciesReactivity |
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| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgeneisamultifunctional,nuclearphosphoproteinthatplaysaroleincellcycleprogression,apoptosisandcellulartransformation.Itfunctionsasatranscriptionfactorthatregulatestranscriptionofspecifictargetgenes.Mutations,overexpression,rearrangementandtranslocationofthisgenehavebeenassociatedwithavarietyofhematopoietictumors,leukemiasandlymphomas,includingBurkittlymphoma.Thereisevidencetoshowthatalternativetranslationinitiationsfromanupstream,in-framenon-AUG(CUG)andadownstreamAUGstartsiteresultintheproductionoftwoisoformswithdistinctN-termini.Thesynthesisofnon-AUGinitiatedproteinissuppressedinBurkitt"slymphomas,suggestingitsimportanceinthenormalfunctionofthisgene. |
| GeneSymbol |
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| Non-ReactiveSpecies |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P01106#Participatesintheregulationofgenetranscription.BindsDNAbothinanon-specificmannerandalsospecificallytorecognizesthecoresequence5"-CAC[GA]TG-3".Seemstoactivatethetranscriptionofgrowth-relatedgenes. SIZE:439aminoacids;48804Da SUBUNIT:EfficientDNAbindingrequiresdimerizationwithanotherbHLHprotein.BindsDNAasaheterodimerwithMAX.InteractswithTAF1CandSPAG9.InteractswithPARP10.InteractswithJARID1AandJARID1B. SUBCELLULARLOCATION:Nucleus. PTM:PhosphorylatedbyPRKDC. DISEASE:SwissProt:P01106#OverexpressionofMYCisimplicatedintheetiologyofavarietyofhematopoietictumors.&AchromosomalaberrationinvolvingMYCmaybeacauseofaformofB-cellchroniclymphocyticleukemia.Translocationt(8;12)(q24;q22)withBTG1. SIMILARITY:SwissProt:P01106##Contains1basichelix-loop-helix(bHLH)domain. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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