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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/CBL430 | Anti-c-myc Antibody, clone 9E10/CBL430/100 µg
商品详细Millipore/CBL430 | Anti-c-myc Antibody, clone 9E10/CBL430/100 µg
Millipore/CBL430 | Anti-c-myc Antibody, clone 9E10/CBL430/100 µg
Millipore/CBL430 | Anti-c-myc Antibody, clone 9E10/CBL430/100 µg
商品编号: CBL430
品牌: 密理博
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberCBL430
BrandFamilyChemicon®
TradeName
  • Chemicon
DescriptionAnti-c-mycAntibody,clone9E10
ProductInformation
FormatPurified
PresentationThemonoclonalispresentedataconcentrationof100μg/1mlinphosphatebufferedsalinecontaining10mMsodiumazideand1mg/mlbovineserumalbumin.Werecommendthateachlaboratorydetermineanoptimumworkingtitreforuseinitsparticularapplication.
StorageandShippingInformation
StorageConditionsForusewithin1monthofpurchasestoreat+4°C,forlongtermstoragealiquotantibodyintosmallvolumesandstoreat-20°C.
Applications
ApplicationAnti-c-mycAntibody,clone9E10isaMouseMonoclonalAntibodyfordetectionofc-mycalsoknownasProto-oncogenec-Myc&hasbeentestedinWB,IHC(P).
KeyApplications
  • WesternBlotting
  • Immunohistochemistry(Paraffin)
ApplicationNotesEpitopetaggingonsequenceEQKLISEEDL

Westernblottingofmyc-taggedrecombinantproteinsandrecombinantmyc

Immunohistochemicalstainingofformalinandfixedparaffinembeddedtissuesectionsandalsoacetonefixedfrozensections

Optimalworkingdilutionsmustbedeterminedbytheenduser.
BIOLOGicalInformation
ImmunogenSyntheticpeptidecorrespondingtothecarboxyterminalofhumanc-myc
Epitopea.a.408-438
Clone9E10
HostMouse
SpecificityKNOWNSPECIESCROSSREACTIVITY:Weaklycross-reactivewithmousebutnotrat
IsotypeIgG1
SpeciesReactivity
  • Human
  • Mouse
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
EntrezGeneSummaryTheproteinencodedbythisgeneisamultifunctional,nuclearphosphoproteinthatplaysaroleincellcycleprogression,apoptosisandcellulartransformation.Itfunctionsasatranscriptionfactorthatregulatestranscriptionofspecifictargetgenes.Mutations,overexpression,rearrangementandtranslocationofthisgenehavebeenassociatedwithavarietyofhematopoietictumors,leukemiasandlymphomas,includingBurkittlymphoma.Thereisevidencetoshowthatalternativetranslationinitiationsfromanupstream,in-framenon-AUG(CUG)andadownstreamAUGstartsiteresultintheproductionoftwoisoformswithdistinctN-termini.Thesynthesisofnon-AUGinitiatedproteinissuppressedinBurkitt"slymphomas,suggestingitsimportanceinthenormalfunctionofthisgene.
GeneSymbol
  • MYC
  • C-MYC
  • c-Myc
Non-ReactiveSpecies
  • Rat
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P01106#Participatesintheregulationofgenetranscription.BindsDNAbothinanon-specificmannerandalsospecificallytorecognizesthecoresequence5"-CAC[GA]TG-3".Seemstoactivatethetranscriptionofgrowth-relatedgenes.
SIZE:439aminoacids;48804Da
SUBUNIT:EfficientDNAbindingrequiresdimerizationwithanotherbHLHprotein.BindsDNAasaheterodimerwithMAX.InteractswithTAF1CandSPAG9.InteractswithPARP10.InteractswithJARID1AandJARID1B.
SUBCELLULARLOCATION:Nucleus.
PTM:PhosphorylatedbyPRKDC.
DISEASE:SwissProt:P01106#OverexpressionofMYCisimplicatedintheetiologyofavarietyofhematopoietictumors.&AchromosomalaberrationinvolvingMYCmaybeacauseofaformofB-cellchroniclymphocyticleukemia.Translocationt(8;12)(q24;q22)withBTG1.
SIMILARITY:SwissProt:P01106##Contains1basichelix-loop-helix(bHLH)domain.
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。