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Millipore/04-217 | Anti-phospho-c-Myc (Thr58/Ser62) Antibody, rabbit monoclonal/04-217/100 µL
Millipore/04-217 | Anti-phospho-c-Myc (Thr58/Ser62) Antibody, rabbit monoclonal/04-217/100 µL
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 04-217 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-phospho-c-Myc(Thr58/Ser62)Antibody,rabbitmonoclonal |
| AlternateNames |
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| BackgroundInformation | Mycisamemberofthehelix-loop-helix-leucinezipper(bHLH-LZ)familyoftranscriptionfactors,whichdimerizeswithMaxtoactivatetranscriptionofsomegenesandrepressothers.AsMaxisessentialforMycactivity,theavailABIlityofMaxisaregulatorymechanismforMycactivity,andmembersoftheMadfamilyofproteinscompetewithMycforMax. |
| ProductInformation | |
|---|---|
| Format | CultureSupernatant |
| Control |
|
| Presentation | 100μLofrabbitmonoclonalIgGin60%storagebuffer(50mMTris-Glycine(pH7.4),0.15MNaCl,0.01%sodiumazideand0.05%BSA)and40%glycerol. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt. HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:Variabilityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptidecorrespondingtosequencesurroundingandincludingphosphorylatedThr58andSer62ofhumanc-Myc. |
| Epitope | phosphorylatedThr58/Ser62 |
| Host | Rabbit |
| Specificity | c-MycwhenphosphorylatedonresiduesThr58/Ser62. |
| Isotype | IgG |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgeneisamultifunctional,nuclearphosphoproteinthatplaysaroleincellcycleprogression,apoptosisandcellulartransformation.Itfunctionsasatranscriptionfactorthatregulatestranscriptionofspecifictargetgenes.Mutations,overexpression,rearrangementandtranslocationofthisgenehavebeenassociatedwithavarietyofhematopoietictumors,leukemiasandlymphomas,includingBurkittlymphoma.Thereisevidencetoshowthatalternativetranslationinitiationsfromanupstream,in-framenon-AUG(CUG)andadownstreamAUGstartsiteresultintheproductionoftwoisoformswithdistinctN-termini.Thesynthesisofnon-AUGinitiatedproteinissuppressedinBurkitt"slymphomas,suggestingitsimportanceinthenormalfunctionofthisgene. |
| GeneSymbol |
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| Modifications |
|
| Non-ReactiveSpecies |
|
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P01106#Participatesintheregulationofgenetranscription.BindsDNAbothinanon-specificmannerandalsospecificallytorecognizesthecoresequence5"-CAC[GA]TG-3".Seemstoactivatethetranscriptionofgrowth-relatedgenes. SIZE:439aminoacids;48804Da SUBUNIT:EfficientDNAbindingrequiresdimerizationwithanotherbHLHprotein.BindsDNAasaheterodimerwithMAX.InteractswithTAF1CandSPAG9.InteractswithPARP10.InteractswithJARID1AandJARID1B. SUBCELLULARLOCATION:Nucleus. PTM:PhosphorylatedbyPRKDC. DISEASE:SwissProt:P01106#OverexpressionofMYCisimplicatedintheetiologyofavarietyofhematopoietictumors.&AchromosomalaberrationinvolvingMYCmaybeacauseofaformofB-cellchroniclymphocyticleukemia.Translocationt(8;12)(q24;q22)withBTG1. SIMILARITY:SwissProt:P01106##Contains1basichelix-loop-helix(bHLH)domain. |
| MolecularWeight | 57kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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