密理博/16-219 |抗Myc标记抗体，克隆4A6，琼脂糖结合物/16-219/100µ；G
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 16-219 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-MycTagAntibody,clone4A6,agaroseconjugate |
| BackgroundInformation | Epitopetagsareshortpeptidesequencesthatareeasilyrecognizedbytag-specificantibodies.Duetotheirsmallsize,epitopetagsdonotaffectthetaggedprotein’sbiochemicalproperties.MostoftensequencesencodingtheepitopetagareincludedwithtargetDNAatthetimeofcloningtoproducefusionproteinscontainingtheepitopetagsequence.Thisallowsanti-epitopetagantibodiestoserveasuniversaldetectionreagentsforanytagcontainingproteinproducedbyrecombinantmeans.Thismeansthatanti-epitopetagantibodiesareausefulalternativetogeneratingspecificantibodiestoidentify,immunoprecipitateorimmunoaffinitypurifyarecombinantprotein.Theanti-epitopetagantibodyisusuallyfunctionalinavarietyofantibody-dependentexperimentalprocedures.Expressionvectorsproducingepitopetagfusionproteinsareavailableforavarietyofhostexpressionsystemsincludingbacteria,yeast,insectandmammaliancells. |
| ProductInformation | |
|---|---|
| Format | GelImmobilized |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgG1covalentlycoupledtoproteinGagarosebeadsandprovidedasa50%slurryinbuffercontainingPBS,pH7.4,and0.05%sodiumazide.LiquidsUSPension. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8ºCfromdateofreceipt.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugated,syntheticpeptidecorrespondingtoaminoacids410-420(MEQKLISEEDL)ofhumanMyc. |
| Clone | 4A6 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | RecognizesandisspecificforrecombinantproteinscontainingtheMycepitopetag(EQKLISEEDL)inavarietyofsequencecontexts.AlsorecognizeshumanMyc. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Human.Reactivitywithotherspecieshasnotbeenconfirmed. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgeneisamultifunctional,nuclearphosphoproteinthatplaysaroleincellcycleprogression,apoptosisandcellulartransformation.Itfunctionsasatranscriptionfactorthatregulatestranscriptionofspecifictargetgenes.Mutations,overexpression,rearrangementandtranslocationofthisgenehavebeenassociatedwithavarietyofhematopoietictumors,leukemiasandlymphomas,includingBurkittlymphoma.Thereisevidencetoshowthatalternativetranslationinitiationsfromanupstream,in-framenon-AUG(CUG)andadownstreamAUGstartsiteresultintheproductionoftwoisoformswithdistinctN-termini.Thesynthesisofnon-AUGinitiatedproteinissuppressedinBurkitt"slymphomas,suggestingitsimportanceinthenormalfunctionofthisgene. |
| GeneSymbol |
|
| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P01106#Participatesintheregulationofgenetranscription.BindsDNAbothinanon-specificmannerandalsospecificallytorecognizesthecoresequence5"-CAC[GA]TG-3".Seemstoactivatethetranscriptionofgrowth-relatedgenes. SIZE:439aminoacids;48804Da SUBUNIT:EfficientDNAbindingrequiresdimerizationwithanotherbHLHprotein.BindsDNAasaheterodimerwithMAX.InteractswithTAF1CandSPAG9.InteractswithPARP10.InteractswithJARID1AandJARID1B. SUBCELLULARLOCATION:Nucleus. PTM:PhosphorylatedbyPRKDC. DISEASE:SwissProt:P01106#OverexpressionofMYCisimplicatedintheetiologyofavarietyofhematopoietictumors.&AchromosomalaberrationinvolvingMYCmaybeacauseofaformofB-cellchroniclymphocyticleukemia.Translocationt(8;12)(q24;q22)withBTG1. SIMILARITY:SwissProt:P01106##Contains1basichelix-loop-helix(bHLH)domain. |
| MolecularWeight | Varies |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
联络我们
