Millipore/16-213 | Anti-Myc Tag Antibody, clone 4A6, HRP conjugate/16-213/100 µL-免疫在线蚂蚁淘旗下平台

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商品详细Millipore/16-213 | Anti-Myc Tag Antibody, clone 4A6, HRP conjugate/16-213/100 µL

Millipore/16-213 | Anti-Myc Tag Antibody, clone 4A6, HRP conjugate/16-213/100 µL

商品编号： 16-213

品牌：密理博

市场价： ¥7400.00

美元价： 4440.00

产地：美国(厂家直采)

公司：

产品分类：功能性抗体

公司分类： Functional_antibody

联系Q Q： 3392242852

电话号码： 4000-520-616

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商品介绍

Description
Catalogue Number	16-213
Brand Family	Upstate
Trade Name	Upstate
Description	Anti-Myc Tag Antibody, clone 4A6, HRP conjugate
Overview	Immunogen: peptide corresponding to amino acids 410-420 (MEQKLISEEDL) of human Myc Specificity: Recognizes and is specific for recombinant proteins containing the Myc epitope tag (EQKLISEEDL) in a variety of sequence contexts. Also recognizes human Myc. Species Cross-reactivity: Human, others not tested Ig Type: IgG Host: Mouse Molecular Weight: Varies depending upon the protein which is tagged
Alternate Names	Transcription factor p64 avian myelocytomatosis viral oncogene homolog myc proto-oncogene protein v-myc avian myelocytomatosis viral oncogene homolog v-myc myelocytomatosis viral oncogene homolog (avian)
Background Information	Myc-Tag is a short synthetic peptide sequence derived from C-terminal region of human c-myc that is used as an epitope tag. The Myc tag can be cloned either upstream or downstream of the target gene, resulting in a fusion protein that allows efficient purification, detection, and localization of target proteins. The relatively small size of this tag vs. other commonly used tags such as GST (30 kDa) makes it less likely to interfere with target protein structure or function. The myc epitope tag is widely used to detect expression of recombinant proteins in bacterial, yeast, insect, and mammalian systems.

Product Information
Format	HRP
Control	Positive control for human Myc: Widespread expression including A431 cell lysate, ovarian cancer cell lysate, or breast carcinoma tissue. Myc fusion protein expressed in cells.
Presentation	Purified mouse monoclonal IgG1 conjugated to horseradish peroxidase (HRP) in buffer containing: 50% storage buffer (PBS, 0.05% Kathon®, 0.2 mg/mL BSA) and 50% glycerol.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20ºC from date of receipt.

Applications
Application	Anti-Myc Tag Antibody, clone 4A6, HRP conjugate detects level of Myc Tag & has been published & validated for use in WB.
Key Applications	Western Blotting

Biological Information
Immunogen	KLH-conjugated, synthetic peptide corresponding to amino acids 410-420 (MEQKLISEEDL) of human Myc. Clone 4A6.
Epitope	C-terminal
Clone	4A6
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Specificity	Recognizes and is specific for recombinant proteins containing the Myc epitope tag (EQKLISEEDL) in a variety of sequence contexts. Also recognizes human Myc.
Species Reactivity	Human
Species Reactivity Note	Human. Other species cross-reactivity not tested.
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_002458
Entrez Gene Summary	The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
Gene Symbol	MYC C-MYC c-Myc
Purification Method	Protein G Purified
UniProt Number	P01106
UniProt Summary	FUNCTION: SwissProt: P01106 # Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes. SIZE: 439 amino acids; 48804 Da SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with JARID1A and JARID1B. SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated by PRKDC. DISEASE: SwissProt: P01106 # Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. & A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1. SIMILARITY: SwissProt: P01106 ## Contains 1 basic helix-loop-helix (bHLH) domain.
Molecular Weight	Varies depending upon the protein which is tagged.

Physicochemical Information

Dimensions

Materials Information

Materials Information

品牌介绍

密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。

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