微孔/MABN50A4 |抗Olig2抗体，克隆211F1.1，Alexa Fluor®488结合物| MABN50A4/MABN50A4/100µ；L-免疫在线蚂蚁淘旗下平台

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商品详细微孔/MABN50A4 |抗Olig2抗体，克隆211F1.1，Alexa Fluor®488结合物| MABN50A4/MABN50A4/100µ；L

微孔/MABN50A4 |抗Olig2抗体，克隆211F1.1，Alexa Fluor®488结合物| MABN50A4/MABN50A4/100µ；L

商品编号： MABN50A4

品牌：密理博

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产地：美国(厂家直采)

公司：

产品分类：功能性抗体

公司分类： Functional_antibody

联系Q Q： 3392242852

电话号码： 4000-520-616

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商品介绍

Description
Catalogue Number	MABN50A4
Description	Anti-Olig2 Antibody, clone 211F1.1, Alexa Fluor®488 Conjugate \| MABN50A4
Alternate Names	Oligodendrocyte transcription factor 2 Oligo2 Class B basic helix-loop-helix protein 1 bHLHb1 Class E basic helix-loop-helix protein 19 bHLHe19 Protein kinase C-binding protein 2 Protein kinase C-binding protein RACK17
Background Information	Oligodendrocyte lineage transcription factor 2 (Olig2) is a protein belonging to group A of the OLIG family of basic helix-loop-helix transcription factors (bHLH). bHLH proteins are divided into 6 groups (A-F), and characterized by their biochemical properties and structure. Olig2 is classified as group A due to its ability to form heterodimers with other bHLH proteins and binding to the E box. Olig2 has a crucial role during development in specifying the final location of motor neurons and oligodendrocytes in the spinal cord, along with the development within the hindbrain of somatic motor neurons. Olig2 expression is observed within oligodendrocytes and in developing astrocytes. Recent studies have shown strong expression of Olig2 in human oligodendrogliomas, primary tumors within the central nervous system, and moderate expression in astrocytomas. These observations have led to the proposal of Olig2 having potential as an oligodendroglioma diagnostic marker.

Product Information
Format	AlexaFluor®488
Control	Rat oligodendrocyte precursor cells
Presentation	Purified mouse monoclonal IgG2a conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Storage and Shipping Information
Storage Conditions	Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Applications
Key Applications	Immunocytochemistry

Biological Information
Immunogen	Recombinant protein corresponding to human Olig2.
Clone	211F1.1
Host	Mouse
Isotype	IgG2a
Species Reactivity	Rat Mouse Human
Species Reactivity Note	Demonstrated to react with mouse and rat. Predicted to react with human based on 100% sequence homology
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_005797
Entrez Gene Summary	This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008].
Gene Symbol	OLIG2 BHLHB1 BHLHE19 PRKCBP2 RACK17
Purification Method	Protein G Purified
UniProt Number	Q13516
UniProt Summary	FUNCTION: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity). SIZE: 323 amino acids; 32385 Da SUBUNIT: Interacts with NKX2-2 (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2 (By similarity). TISSUE SPECIFICITY: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. DOMAIN: The bHLH is essential for interaction with NKX2-2 (By similarity).DISEASE:SwissProt: Q13516 # A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA. SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain.
Molecular Weight	The unconjugated parent antibody (Cat. No. MABN50) has an observed molecular weight at ~37 kDa.

Physicochemical Information

Dimensions

Materials Information

Materials Information

品牌介绍

密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。

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细胞分析蛋白质样品制备细胞培养与系统蛋白质和酶抗体和化验抗体和化验蛋白质检测与定量生命科学研究抑制剂和生化物质

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