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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/MAB5680 | Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody/MAB5680/100 µg
商品详细Millipore/MAB5680 | Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody/MAB5680/100 µg
Millipore/MAB5680 | Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody/MAB5680/100 µg
Millipore/MAB5680 | Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody/MAB5680/100 µg
商品编号: MAB5680
品牌: 密理博
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberMAB5680
BrandFamilyChemicon®
TradeName
  • Chemicon
DescriptionAnti-MyelinOligodendrocyteGlycoprotein(MOG)Antibody
AlternateNames
  • MOG
BackgroundInformationMyelinoligodendrocyteglycoprotein(MOG)isakeyCNS-specificautoantigenforprimarydemyelinationinmultiplesclerosis.Althoughthedisease-inducingroleofMOGhasbeenestablished,itsprecisefunctionintheCNSremainsobscure.MOGisatypeIintegralmembraneproteinpossessingasingleextracellularIgvariabledomain(Ig-V)(3,13,14).TheaminoacidsequenceofMOGishighlyconservedamonganimalspecies(>90%),indicativeofanimportantBIOLOGicalfunction.MOGisspecificallyexpressedintheCNSontheoutermostlamellaeofthemyelinsheathaswellasthecellbodyandprocessesofoligodendrocytes.ThedevelopmentallylateexpressionofMOGcorrelateswiththelaterstagesofmyelinogenesis,suggestingthatMOGhasaroleinthecompletion,compaction,and/ormaintenanceofmyelin,furthersuggestingthatMOGhasanadhesivefunctionwithintheCNS.ConsistentwithMOG"spossIBLeadhesiveroleintheCNS,ahomodimericformofMOGhasnotonlybeenobservedafterisolationfromtheCNSbuthasadditionallybeenobservedinsitu.
ProductInformation
FormatPurified
Control
  • brainlysate
PresentationPurifiedinPBSwith0.05%NaN3.
StorageandShippingInformation
StorageConditionsMaintainat2-8°Cinundilutedaliquotsforupto1yearafterdateofreceipt.
Applications
ApplicationAnti-MyelinOligodendrocyteGlycoprotein(MOG)AntibodyisanantibodyagainstMyelinOligodendrocyteGlycoprotein(MOG)foruseinFC,IC,IH&WB.
KeyApplications
  • FlowCytometry
  • Immunocytochemistry
  • Immunohistochemistry
  • WesternBlotting
BiologicalInformation
ImmunogenRatcerebellarglycoproteins
EpitopeTheantibodybindstoadiscontinuousepitopepresentontheextracellularimmunoglobulinV-likedomainofMOG.
Clone8-18C5
ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
HostMouse
SpecificityMembaneassociatedregionofMOG[Myelinoligodendrocyteglycoprotein].
IsotypeIgG1
SpeciesReactivity
  • Mouse
  • Rat
SpeciesReactivityNoteMaycrossreactwithhumanandbovinebasedonsequencesimilarity.
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
PurificationMethodPurifiedimmunoglobulin
UniProtNumber
UniProtSummaryFUNCTION:Minorcomponentofthemyelinsheath.Maybeinvolvedincompletionand/ormaintenanceofthemyelinsheathandincell-cellcommunication.
SUBUNIT:Mayformhomodimers.
SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein.
TISSUESPECIFICITY:FoundexclusivelyintheCNS,whereitislocalizedonthesurfaceofmyelinandoligodendrocytecytoplasmicmembranes.
DEVELOPMENTALSTAGE:Apeakofexpressionhasbeenobservedbetweenpostnataldays15and25,coincidingwiththeperiodofactivemyelination.
SIMILARITY:Belongstotheimmunoglobulinsuperfamily.BTN/MOGfamily.
SIMILARITY:Contains1Ig-likeV-type(immunoglobulin-like)domain.
CAUTION:Donotconfusemyelin-oligodendrocyteglycoprotein(MOG)witholigodendrocyte-myelinglycoprotein(OMG).
MolecularWeight28kDa
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。