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Millipore/MAB388-100UG | Anti-Myelin Proteolipid Protein Antibody, CT, clone PLPC1/MAB388-100UG/100 µg
Millipore/MAB388-100UG | Anti-Myelin Proteolipid Protein Antibody, CT, clone PLPC1/MAB388-100UG/100 µg
商品编号：
MAB388-100UG
品牌：
密理博
市场价：
¥7400.00
美元价：
4440.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB388-100UG |
| Replaces | MAB388 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-MyelinProteolipidProteinAntibody,CT,clonePLPC1 |
| AlternateNames |
|
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedmouseimmunoglobulininPBS,pH7.2containing0.09%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainfor1yearat-20°Cfromdateofshipment.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap. |
| Applications | |
|---|---|
| Application | DetectMyelinProteolipidProteinusingthisAnti-MyelinProteolipidProteinAntibody,C-terminus,clonePLPC1validatedforuseinIH,IH(P)&WB. |
| KeyApplications |
|
| ApplicationNotes | WesternBlotting:detectsa23-25kDaproteinandDM20a20kDaprotein;PLPcanaggregatecausingHMWbandstosometimesappearincertainpreparations. Immunocytochemistry:4%PFAfixedcells,5-10minutesroomtemperature.Use0.1%tritoninblockonlytoallowantibodyaccesstoC-terminalepitope. Immunohistologyonfreshfrozensectionsor4%PFAfixed,frozentissues.Epitopeisinternal,use0.1-0.2%tritonX-100intheblockingstepforpermeABIlization. Immunohistochemistryinparaffin:worksbestwithlightlyfixedtissues,orBouin"sfixedmaterial,althoughtherearereportsoftrADItionalformalinfixationalsoworkingwithantigenrecovery.{Mathis,etal2003}. Optimalworkingdilutionsmustbedeterminedbyenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Myelinproteolipidprotein,syntheticpeptideCGRGTKFcorrespondingtotheC-terminalpeptide. |
| Epitope | C-terminus |
| Clone | PLPC1 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | Reactswithmyelinproteolipidproteininmanymammalianspecies.Showscross-reactivitytoDM20. |
| Isotype | IgG2a |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesatransmembraneproteolipidproteinthatisthepredominantmyelinproteinpresentinthecentralnervoussystem.Itmayplayaroleinthecompaction,stabilization,andmaintenanceofmyelinsheaths,aswellasinoligodendrocytedevelopmentandaxonalsurvival.MutationsinthisgenecauseX-linkedPelizaeus-Merzbacherdiseaseandspasticparaplegiatype2.Alternativelysplicedtranscriptvariantsencodingdistinctisoformsorhavingdifferent5"UTRs,havebeenidentifiedforthisgene. |
| GeneSymbol |
|
| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P60201#Thisisthemajormyelinproteinfromthecentralnervoussystem.Itplaysanimportantroleintheformationormaintenanceofthemultilamellarstructureofmyelin. SIZE:277aminoacids;30,077Da SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. PTM:Lipoprotein,Palmitate DISEASE:DefectsinPLP1arethecauseofPelizaeus-Merzbacherdisease(PMD)[MIM:312080].PMDisanX-linkedneurologicdisorderofmyelinmetabolism.Itischaracterizedbyearlyimpairmentofmotordevelopment(duringthefirstthreemonthsoflife)and,later,bythedevelopmentofabnormalmovementsandprogressivespasticparaplegia. SIMILARITY:Belongstothemyelinproteolipidproteinfamily. |
| MolecularWeight | 23-25kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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