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Millipore/MAB079-1 |抗S-100蛋白抗体，克隆15E2E2/MAB079-1/100µ；L@1 mg/mL浓度
Millipore/MAB079-1 |抗S-100蛋白抗体，克隆15E2E2/MAB079-1/100µ；L@1 mg/mL浓度
市场价：
¥5740.00
美元价：
3444.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB079-1 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-S-100ProteinAntibody,clone15E2E2 |
| AlternateNames |
|
| BackgroundInformation | S-100proteinisamemberoftheEF-handcalcium-bindingproteinsuperfamilythatiswidelydistributedandconservedinthecentralnervoussystemofvertebrates.Theproteinexistsinbothheterodimericandhomodimericforms.ThetwosubunitsofS-100proteinaretheproductsofseparategenesthataredifferentiallyexpressedbyvariouscells.ThebetasubunitispresentinallS-100positivecellsandtumors.Incontrast,thealphasubunitisdetectableonlyinheart,skeletalmuscleandbrain.Inadditiontoitscalciumbindingproperties,S-100proteinhasahigh-affinitybindingsiteforzincandisinvolvedintheregulationofproteinphosphorylationinthebrain.Theproteinapparentlyplaysaroleincelldifferentiationandgrowth,cytoskeletalstructureandfunction,andhasbeenimplicatedinneuropathologicaldiseases. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgG2aκinbuffercontainingPBS,pH7.6,1%BSAand0.09%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8ºCfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | PurifiedbovineS-100protein |
| Epitope | Recognizesbothalpha&betaS100 |
| Clone | 15E2E2 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | Recognizesintact,alphaandbetasubunitsofbovine,human,andmurineS-100protein,asdeterminedbyimmunoprecipitationprofiles. |
| Isotype | IgG2aκ |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | TheproteinencodedbythisgeneisamemberoftheS100familyofproteinscontaining2EF-handcalcium-bindingmotifs.S100proteinsarelocalizedinthecytoplasmand/ornucleusofawiderangeofcells,andinvolvedintheregulationofanumberofcellularprocessessuchascellcycleprogressionanddifferentiation.S100genesincludeatleast13memberswhicharelocatedasaclusteronchromosome1q21.ThisproteinmayfunctioninstimulationofCa2+-inducedCa2+release,inhibitionofmicrotubuleassembly,andinhibitionofproteinkinaseC-mediatedphosphorylation.Reducedexpressionofthisproteinhasbeenimplicatedincardiomyopathies. |
| GeneSymbol |
|
| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P23297#Weaklybindscalciumbutbindszincverytightly-distinctbindingsiteswithdifferentaffinitiesexistforbothionsoneachmonomer.Physiologicalconcentrationsofpotassiumionantagonizethebindingofbothdivalentcations,especiallyaffectinghigh-affinitycalcium-bindingsites. SIZE:94aminoacids;10546Da SUBUNIT:Dimerofeithertwoalphachains,ortwobetachains,oronealphaandonebetachain. SUBCELLULARLOCATION:Cytoplasm. TISSUESPECIFICITY:Highlyprevalentinheart.Alsofoundinlesserquantitiesinskeletalmuscleandbrain. SIMILARITY:SwissProt:P23297##BelongstotheS-100family.&Contains2EF-handdomains. |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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