密理博/CBL1366 |抗CD140a抗体，克隆APA5/CBL1366/100µ；G
市场价：
¥5740.00
美元价：
3444.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | CBL1366 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-CD140aAntibody,cloneAPA5 |
| AlternateNames |
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| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | PurifiedimmunoglobulininPBS,150mMNaCl,pH7.2,containing0.09%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat2-8°Cforupto12monthsfromdateofreceipt. |
| Applications | |
|---|---|
| Application | DetectCD140ausingthisAnti-CD140aAntibody,cloneAPA5validatedforuseinELISA,FC,WB,IH. |
| KeyApplications |
|
| ApplicationNotes | FlowCytometry:<=1=""μg=""per=""10e6=""cells=""> ELISA Immunohistochemistry:10μg/mL BlockingofLigandBinding WesternBlotting Optimalworkingdilutionsmustbedeterminedbytheenduser. |
| BIOLOGicalInformation | |
|---|---|
| Clone | APA5 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rat |
| Specificity | SpecificallyrecognizesmouseCD140a,thealphachainofPDGFreceptor.Areceptortyrosinekinase,PDGFRaformsdimersonthesurfaceuponligandbindingandphosphorylatessubstrates.CD140aisexpressedbyembryonictissuesandmesenchymal-derivedcellsoftheadultmousetissues. |
| Isotype | IgG2aκ |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesacellsurfacetyrosinekinasereceptorformembersoftheplatelet-derivedgrowthfactorfamily.Thesegrowthfactorsaremitogensforcellsofmesenchymalorigin.Theidentityofthegrowthfactorboundtoareceptormonomerdetermineswhetherthefunctionalreceptorisahomodimeroraheterodimer,composedofbothplatelet-derivedgrowthfactorreceptoralphaandbetapolypeptides.Studiesinknockoutmice,wherehomozygosityislethal,indicatethatthealphaformoftheplatelet-derivedgrowthfactorreceptorisparticularlyimportantforkidneydevelopmentsincemiceheterozygousforthereceptorexhibitdefectivekidneyphenotypes. |
| GeneSymbol |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P16234#ReceptorthatbindsbothPDGFAandPDGFBandhasatyrosine-proteinkinaseactivity. SIZE:1089aminoacids;122670Da SUBUNIT:Homodimer,andheterodimerwithPDGFRB.InteractswithSHB(Bysimilarity). SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. DISEASE:SwissProt:P16234#AfusionofPDGFRAandFIP1L1(FIP1L1-PDGFRA),duetoaninterstitialchromosomaldeletion,isthecauseofsomecasesofhypereosinophilicsyndrome(HES)[MIM:607685].HESisararehematologicdisordercharacterizedbysustainedoverproductionofeosinophilsinthebonemarrow,eosinophilia,tissueinfiltrationandorgandamage. SIMILARITY:SwissProt:P16234##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.CSF-1/PDGFreceptorsubfamily.&Contains5Ig-likeC2-type(immunoglobulin-like)domains.&Contains1proteinkinasedomain. |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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