密理博/AB9906 |抗QKI-6抗体/AB9906/100µ；L
市场价：
¥6980.00
美元价：
4188.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB9906 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-QKI-6Antibody |
| AlternateNames |
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| BackgroundInformation | QKIisanRNA-bindingproteinthatplaysacentralroleinmyelinization.Actsbyregulatingpre-mRNAsplicing,mRNAexport,mRNAstABIlityandproteintranslation.Itisregulatedbyalternativesplicing. |
| ProductInformation | |
|---|---|
| Format | Serum |
| Control |
|
| Presentation | Liquid. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cinundilutedaliquotsforupto12monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles. |
| Applications | |
|---|---|
| Application | Anti-QKI-6AntibodydetectslevelofQKI-6&hasbeenpublished&validatedforuseinIP&WB. |
| KeyApplications |
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| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptidefrommouseQKI-6. |
| Host | Rabbit |
| Specificity | QKI-6(QuakingProtein).Theantibodyrecognizesthe~38kDaprotein. |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | QKIbelongstoafamilyofRNA-bindingproteinsthathaveanHNRNPK(MIM600712)homology(KH)domainembeddedina200-aminoacidregioncalledtheGSGdomain.OthermembersofthisfamilyincludeSAM68(KHDRBS1;MIM602489)andSF1(MIM601516)(ChenandRichard,1998[PubMed9671495]).[suppliedbyOMIM] |
| GeneSymbol |
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| PurificationMethod | Serum |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q96PU8#RNA-bindingproteinthatplaysacentralroleinmyelinization.Bindstothe5"-NACUAAY-N(1,20)-UAAY-3"RNAcoresequence.Actsbyregulatingpre-mRNAsplicing,mRNAexport,mRNAstabilityandproteintranslation.RequiredtoprotectandpromotestabilityofmRNAssuchasMBPandCDKN1Bwhichpromotesoligodendrocytedifferentiation.ParticipatesinmRNAtransportbyregulatingthenuclearexportofMBPmRNA.AlsoinvolvedinregulationofmRNAsplicingofMAGpre-mRNA.Actsasatranslationalrepressor(Bysimilarity). SIZE:341aminoacids;37671Da SUBUNIT:Homodimer.DoesnotrequireRNAtohomodimerize.AbletoheterodimerizewithBICC1(Bysimilarity). SUBCELLULARLOCATION:Nucleus(Bysimilarity).Cytoplasm(Bysimilarity). TISSUESPECIFICITY:Expressedinthefrontalcortexofbrain. PTM:MethylatedbyPRMT1(Bysimilarity).&TyrosinephosphorylatedatitsC-terminus,probablybyFYN.PhosphorylationleadstodecreasedmRNA-bindingaffinity,affectingtransportand/orstabilizationofMBPmRNA(Bysimilarity). DISEASE:SwissProt:Q96PU8#Mayplayaroleingeneticsusceptibilitytoschizophrenia.QKIlevelsofsomeisoformssuchasisoform6,arefrequentlydown-regulatedinschizophrenicpatients.&DeletionoftheQKIgenemayplayaroleinastrocytictumors. SIMILARITY:SwissProt:Q96PU8##Contains1KHdomain. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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