
密理博/07-276 |抗PDGFRα抗体/07-276/200µ;L
市场价:
¥5960.00
美元价:
3576.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description | |
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CatalogueNumber | 07-276 |
BrandFamily | Upstate |
TradeName |
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Description | Anti-PDGFRαAntibody |
BackgroundInformation | Plateletderivedgrowthfactorreceptor(PDGFReceptor)isatransmembraneglycoproteinof170-185kDawhichundergoeshomoorheterodimerizationintocomplexesofalphaandbetasubunitsuponligandbinding,dependingontheisoformofPDGF(PDGFAA,BBorAB)thatbinds.Thephosphorylationoftyrosineresiduesinthenowactivatedreceptorcancontrolmultiplesignalingeventssuchasactinreorganization,transcription,cellgrowth,migrationanddifferentiation,andalsoleadtoactivationoftheRas,RafandERK1and2pathway. |
ProductInformation | |
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Format | AffinityPurified |
Control |
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Presentation | ProteinAPurifiedimmunoglobulinin0.14MTris-glycine,pH7.4,0.105MNaCl,0.035%sodiumazideasapreservative. |
StorageandShippingInformation | |
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StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. |
Applications | |
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Application | DetectPDGFRαusingthisAnti-PDGFRαAntibodyvalidatedforuseinIP&WB. |
KeyApplications |
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BIOLOGicalInformation | |
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Immunogen | peptidecorrespondingtoaminoacids1035-1053(C-GKRNRHSSQTSEESAIETG)ofhumanPDGFReceptorα |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | RecognizesPDGFReceptoralpha. |
Isotype | IgG |
SpeciesReactivity |
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AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thisgeneencodesacellsurfacetyrosinekinasereceptorformembersoftheplatelet-derivedgrowthfactorfamily.Thesegrowthfactorsaremitogensforcellsofmesenchymalorigin.Theidentityofthegrowthfactorboundtoareceptormonomerdetermineswhetherthefunctionalreceptorisahomodimeroraheterodimer,composedofbothplatelet-derivedgrowthfactorreceptoralphaandbetapolypeptides.Studiesinknockoutmice,wherehomozygosityislethal,indicatethatthealphaformoftheplatelet-derivedgrowthfactorreceptorisparticularlyimportantforkidneydevelopmentsincemiceheterozygousforthereceptorexhibitdefectivekidneyphenotypes. |
GeneSymbol |
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PurificationMethod | ImmunoAffinityPurified |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P16234#ReceptorthatbindsbothPDGFAandPDGFBandhasatyrosine-proteinkinaseactivity. SIZE:1089aminoacids;122670Da SUBUNIT:Homodimer,andheterodimerwithPDGFRB.InteractswithSHB(Bysimilarity). SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. DISEASE:SwissProt:P16234#AfusionofPDGFRAandFIP1L1(FIP1L1-PDGFRA),duetoaninterstitialchromosomaldeletion,isthecauseofsomecasesofhypereosinophilicsyndrome(HES)[MIM:607685].HESisararehematologicdisordercharacterizedbysustainedoverproductionofeosinophilsinthebonemarrow,eosinophilia,tissueinfiltrationandorgandamage. SIMILARITY:SwissProt:P16234##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.CSF-1/PDGFreceptorsubfamily.&Contains5Ig-likeC2-type(immunoglobulin-like)domains.&Contains1proteinkinasedomain. |
MolecularWeight | 150/170kDa(doublet) |
PhysicochemicalInformation |
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Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。
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