密理博/07-276 |抗PDGFRα抗体/07-276/200µ；L
市场价：
¥5960.00
美元价：
3576.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 07-276 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-PDGFRαAntibody |
| BackgroundInformation | Plateletderivedgrowthfactorreceptor(PDGFReceptor)isatransmembraneglycoproteinof170-185kDawhichundergoeshomoorheterodimerizationintocomplexesofalphaandbetasubunitsuponligandbinding,dependingontheisoformofPDGF(PDGFAA,BBorAB)thatbinds.Thephosphorylationoftyrosineresiduesinthenowactivatedreceptorcancontrolmultiplesignalingeventssuchasactinreorganization,transcription,cellgrowth,migrationanddifferentiation,andalsoleadtoactivationoftheRas,RafandERK1and2pathway. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | ProteinAPurifiedimmunoglobulinin0.14MTris-glycine,pH7.4,0.105MNaCl,0.035%sodiumazideasapreservative. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. |
| Applications | |
|---|---|
| Application | DetectPDGFRαusingthisAnti-PDGFRαAntibodyvalidatedforuseinIP&WB. |
| KeyApplications |
|
| BIOLOGicalInformation | |
|---|---|
| Immunogen | peptidecorrespondingtoaminoacids1035-1053(C-GKRNRHSSQTSEESAIETG)ofhumanPDGFReceptorα |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | RecognizesPDGFReceptoralpha. |
| Isotype | IgG |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesacellsurfacetyrosinekinasereceptorformembersoftheplatelet-derivedgrowthfactorfamily.Thesegrowthfactorsaremitogensforcellsofmesenchymalorigin.Theidentityofthegrowthfactorboundtoareceptormonomerdetermineswhetherthefunctionalreceptorisahomodimeroraheterodimer,composedofbothplatelet-derivedgrowthfactorreceptoralphaandbetapolypeptides.Studiesinknockoutmice,wherehomozygosityislethal,indicatethatthealphaformoftheplatelet-derivedgrowthfactorreceptorisparticularlyimportantforkidneydevelopmentsincemiceheterozygousforthereceptorexhibitdefectivekidneyphenotypes. |
| GeneSymbol |
|
| PurificationMethod | ImmunoAffinityPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P16234#ReceptorthatbindsbothPDGFAandPDGFBandhasatyrosine-proteinkinaseactivity. SIZE:1089aminoacids;122670Da SUBUNIT:Homodimer,andheterodimerwithPDGFRB.InteractswithSHB(Bysimilarity). SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. DISEASE:SwissProt:P16234#AfusionofPDGFRAandFIP1L1(FIP1L1-PDGFRA),duetoaninterstitialchromosomaldeletion,isthecauseofsomecasesofhypereosinophilicsyndrome(HES)[MIM:607685].HESisararehematologicdisordercharacterizedbysustainedoverproductionofeosinophilsinthebonemarrow,eosinophilia,tissueinfiltrationandorgandamage. SIMILARITY:SwissProt:P16234##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.CSF-1/PDGFreceptorsubfamily.&Contains5Ig-likeC2-type(immunoglobulin-like)domains.&Contains1proteinkinasedomain. |
| MolecularWeight | 150/170kDa(doublet) |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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