Millipore/07-1448 | Anti-WAVE-1 Antibody/07-1448/100 µg
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¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 07-1448 |
| Replaces | AB4095 |
| Description | Anti-WAVE-1Antibody |
| AlternateNames |
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| BackgroundInformation | RecognizesWAVE1(Wiskott-Aldrichsyndromeproteinfamilymember1,WASP-familyproteinmember1).WAVE1isadownstreameffectormoleculeinvolvedinthetransmissionofsignalsfromtyrosinekinasereceptorsandsmallGTPasestotheactinCytoskeleton.WAVE1bindsactinandARP2/3complex.ItbindstheARP2/3complexthroughtheC-terminalregionandactinthroughverprolinhomology(VPH)domain. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | Purifiedrabbitpolyclonalinbuffercontaining0.02Mphosphatebuffer,0.25MNaCl,with0.1%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat2-8ºCinundilutedaliquotsforupto12monthsfromdateofreceipt. |
| Applications | |
|---|---|
| Application | ThisAnti-WAVE-1AntibodyisvalidatedforuseinWBforthedetectionofWAVE-1. |
| KeyApplications |
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| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptidecorrespondingtoaninternalaminoacidsequenceofhumanWAVE1.Immunogensequenceisconservedinratandmouse. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | ThisantibodyrecognizesaninternalaminoacidsequenceofWAVE-1. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Reactswithmouseandhuman.Reactivitywithotherspecieshasnotbeendetermined. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgene,amemberoftheWiskott-Aldrichsyndromeprotein(WASP)-family,playsacriticalroledownstreamofRac,aRho-familysmallGTPase,inregulatingtheactincytoskeletonrequiredformembraneruffling.IthasbeenshowntoassociatewithanactinnucleationcoreArp2/3complexwhileenhancingactinpolymerizationinvitro.Wiskott-Aldrichsyndromeisadiseaseoftheimmunesystem,likelyduetodefectsinregulationofactincytoskeleton.Multiplealternativelysplicedtranscriptvariantsencodingthesameproteinhavebeenfoundforthisgene. |
| GeneSymbol |
|
| PurificationMethod | AffinityPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:DownstreameffectormoleculesinvolvedinthetransmissionofsignalsfromtyrosinekinasereceptorsandsmallGTPasestotheactincytoskeleton. SUBUNITSTRUCTURE:ComponentoftheWAVE1complexcomposedofABI2,CYFIP2,C3orf10/HSPC300,NCKAP1andWASF1/WAVE1.CYFIP2bindstoactivatedRAC1whichcausesthecomplextodissociate,releasingactivatedWASF1.ThecomplexcanalsobeactivatedbyNCK1Bysimilarity.BindsactinandtheArp2/3complex.InteractswithBAIAP2. SUBCELLULARLOCATIION:Cytoplasm›cytoskeleton.Note:Dot-likepatterninthecytoplasm.ConcentratedinRac-regulatedmembrane-rufflingareas. TISSUESPECIFICITY:Highlyexpressedinbrain.Lowlyexpressedintestis,ovary,colon,kidney,pancreas,thymus,smallintestineandperipheralblood. DOMAIN:BindstheArp2/3complexthroughtheC-terminalregionandactinthroughverprolinhomology(VPH)domain. SEQUENCESIMILARITIES:BelongstotheSCAR/WAVEfamily. Contains1WH2domain. |
| MolecularWeight | Approx.62kDa |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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