
密理博/07-037 |抗波/疤痕抗体/07-037/100µ;G
市场价:
¥0.00
美元价:
0.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description | |
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CatalogueNumber | 07-037 |
Replaces | AB3821 |
BrandFamily | Upstate |
TradeName |
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Description | Anti-WAVE/ScarAntibody |
ProductInformation | |
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Format | Purified |
Presentation | 0.1MTris-glycine,pH7.4,0.15MNaCl,0.05%sodiumazidebeforetheadditionofglycerolto30% |
StorageandShippingInformation | |
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StorageConditions | 2yearsat-20°C |
Applications | |
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Application | Anti-WAVE/ScarAntibodyisanantibodyagainstWAVE/ScarforuseinIP&WB. |
KeyApplications |
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BIOLOGicalInformation | |
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Immunogen | GSTfusion-proteincorrespondingtofulllength(residues1-559)ofhumanWAVE/Scar |
Host | Rabbit |
Specificity | WAVE/Scar |
Isotype | IgG |
SpeciesReactivity |
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AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Theproteinencodedbythisgene,amemberoftheWiskott-Aldrichsyndromeprotein(WASP)-family,playsacriticalroledownstreamofRac,aRho-familysmallGTPase,inregulatingtheactinCytoskeletonrequiredformembraneruffling.IthasbeenshowntoassociatewithanactinnucleationcoreArp2/3complexwhileenhancingactinpolymerizationinvitro.Wiskott-Aldrichsyndromeisadiseaseoftheimmunesystem,likelyduetodefectsinregulationofactincytoskeleton.Multiplealternativelysplicedtranscriptvariantsencodingthesameproteinhavebeenfoundforthisgene. |
GeneSymbol |
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PurificationMethod | ProteinAchromatography |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:Q92558#DownstreameffectormoleculesinvolvedinthetransmissionofsignalsfromtyrosinekinasereceptorsandsmallGTPasestotheactincytoskeleton. SIZE:559aminoacids;61652Da SUBUNIT:ComponentoftheWAVE1complexcomposedofABI2,CYFIP2,C3orf10/HSPC300,NCKAP1andWASF1/WAVE1.CYFIP2bindstoactivatedRAC1whichcausesthecomplextodissociate,releasingactivatedWASF1.ThecomplexcanalsobeactivatedbyNCK1(Bysimilarity).BindsactinandtheArp2/3complex.InteractswithBAIAP2. SUBCELLULARLOCATION:Cytoplasm,cytoskeleton.Note=Dot-likepatterninthecytoplasm.ConcentratedinRac-regulatedmembrane-rufflingareas. TISSUESPECIFICITY:Highlyexpressedinbrain.Lowlyexpressedintestis,ovary,colon,kidney,pancreas,thymus,smallintestineandperipheralblood. DOMAIN:SwissProt:Q92558BindstheArp2/3complexthroughtheC-terminalregionandactinthroughverprolinhomology(VPH)domain. SIMILARITY:Contains1WH2domain. |
MolecularWeight | 84kDa |
PhysicochemicalInformation |
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Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。
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