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Millipore/04-1054 |抗S100-β（CT）抗体，克隆EP1576Y，兔单克隆/04-1054/100µ；L
Millipore/04-1054 |抗S100-β（CT）抗体，克隆EP1576Y，兔单克隆/04-1054/100µ；L
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 04-1054 |
| Description | Anti-S100-β(CT)Antibody,cloneEP1576Y,rabbitmonoclonal |
| AlternateNames |
|
| BackgroundInformation | S-100proteinisamemberoftheEF-handcalcium-bindingproteinsuperfamilythatiswidelydistributedandconservedinthecentralnervoussystemofvertebrates.Theproteinexistsinbothheterodimericandhomodimericforms.ThetwosubunitsofS-100proteinaretheproductsofseparategenesthataredifferentiallyexpressedbyvariouscells.ThebetasubunitispresentinallS-100positivecellsandtumors.Incontrast,thealphasubunitisdetectableonlyinheart,skeletalmuscleandbrain.Inadditiontoitscalciumbindingproperties,S-100proteinhasahigh-affinitybindingsiteforzincandisinvolvedintheregulationofproteinphosphorylationinthebrain.Theproteinapparentlyplaysaroleincelldifferentiationandgrowth,cytoskeletalstructureandfunction,andhasbeenimplicatedinneuropathologicaldiseases. |
| ProductInformation | |
|---|---|
| Format | Unpurified |
| Control |
|
| Presentation | RabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt. HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptidecorrespondingtoresiduesontheC-terminusofhumanS100-β. |
| Epitope | C-terminus |
| Clone | EP1576Y |
| Host | Rabbit |
| Specificity | ThisantibodyrecognizesS100-βatandaroundtheC-terminus. |
| Isotype | IgG |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | TheproteinencodedbythisgeneisamemberoftheS100familyofproteinscontaining2EF-handcalcium-bindingmotifs.S100proteinsarelocalizedinthecytoplasmand/ornucleusofawiderangeofcells,andinvolvedintheregulationofanumberofcellularprocessessuchascellcycleprogressionanddifferentiation.S100genesincludeatleast13memberswhicharelocatedasaclusteronchromosome1q21;however,thisgeneislocatedat21q22.3.ThisproteinmayfunctioninNeuriteextension,proliferationofmelanomacells,stimulationofCa2+fluxes,inhibitionofPKC-mediatedphosphorylation,astrocytosisandaxonalproliferation,andinhibitionofmicrotubuleassembly.Chromosomalrearrangementsandalteredexpressionofthisgenehavebeenimplicatedinseveralneurological,neoplastic,andothertypesofdiseases,includingAlzheimer"sdisease,Down"ssyndrome,epilepsy,amyotrophiclateralsclerosis,melanoma,andtypeIdiabetes. |
| GeneSymbol |
|
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Weaklybindscalciumbutbindszincverytightly-distinctbindingsiteswithdifferentaffinitiesexistforbothionsoneachmonomer.Physiologicalconcentrationsofpotassiumionantagonizethebindingofbothdivalentcations,especiallyaffectinghigh-affinitycalcium-bindingsites.BindstoandinitiatestheactivationofSTK38byreleasingautoinhibitoryintramolecularinteractionswithinthekinase. SUBUNITSTRUCTURE:Dimerofeithertwoalphachains,ortwobetachains,oronealphaandonebetachain.TheS100BdimerbindstwomoleculesofSTK38Bysimilarity.TheS100BdimerinteractswithtwomoleculesofCAPZA1. SUBCELLULARLOCATION:Cytoplasm.Nucleus. TISSUESPECIFICITY:Althoughpredominantamongthewater-solublebrainproteins,S100isalsofoundinavarietyofothertissues. MISCELLANEOUS:Inadditiontometal-ionbinding,thisproteinisinvolvedwiththeregulationofproteinphosphorylationinbraintissue. SEQUENCESIMILARITIES:BelongstotheS-101family. Contains2EF-handdomains. |
| MolecularWeight | ~11kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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