微孔/MABT149 |抗CD11b/ITAM抗体，克隆EP1345Y，兔单克隆/MABT149/100µ；L
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MABT149 |
| Description | Anti-CD11b/ITAMAntibody,cloneEP1345Y,rabbitmonoclonal |
| AlternateNames |
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| BackgroundInformation | Integrinalpha-M(ITAM,ITGAM,CD11b,MAC-1alphasubunit,CR3alphachain)isthealphasubunitofITAM/beta-2complex(CD11b/CD18,Mac-1),aleukocyteadhesionheterodimericglycoprotein(1).ITAMbelongstointegrinalphachainfamilyanditispredominatelypresentedinhumanmyeloidcells,NK1cells,monocytes,andgranulocytes.ITAM/beta-2complexisareceptorforfibrinogen(bindingtoP1andP1peptidesofgammachain),factorX,andICAM1.ITAM/beta-2isimplicatedinadhesiveinteractionsofmonocytes,macrophages,andgranulocytes.Itisalsolinkedtomediationofcomplement-coatedparticleuptake(2). |
| ProductInformation | |
|---|---|
| Format | DilutedCultureSupernatant |
| Control |
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| Presentation | RabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt.HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptidecorrespondingtohumanCD11b/ITAMattheC-terminus. |
| Epitope | C-terminus |
| Clone | EP1345Y |
| Host | Rabbit |
| Isotype | IgG |
| SpeciesReactivity |
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| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
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| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Integrinalpha-M/beta-2isimplicatedinvariousadhesiveinteractionsofmonocytes,macrophagesandgranulocytesaswellasinmediatingtheuptakeofcomplement-coatedparticles.ItisidenticalwithCR-3,thereceptorfortheiC3bfragmentofthethirdcomplementcomponent.ItprobablyrecognizestheR-G-DpeptideinC3b.Integrinalpha-M/beta-2isalsoareceptorforfibrinogen,factorXandICAM1.ItrecognizesP1andP2peptidesoffibrinogengammachain. SUBUNITSTRUCTURE:Heterodimerofanalphaandabetasubunit.Alpha-Massociateswithbeta-2. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Predominantlyexpressedinmonocytesandgranulocytes. DOMAIN:TheintegrinI-domain(insert)isaVWFAdomain.IntegrinswithI-domainsdonotundergoproteasecleavage. INVOLVEMENTINDISEASE:GeneticvariationsinITGAMhasbeenassociatedwithsusceptibilitytosystemiclupuserythematosustype6(SLEB6)[MIM:609939].Systemiclupuserythematosus(SLE)isachronic,inflammatoryandoftenfebrilemultisystemicdisorderofconnectivetissue.Itaffectsprincipallytheskin,joints,kidneysandSEROsalmembranes.Itisthoughttorepresentafailureoftheregulatorymechanismsoftheautoimmunesystem. SEQUENCESIMILARITIES:Belongstotheintegrinalphachainfamily. Contains7FG-GAPrepeats. Contains1VWFAdomain. |
| MolecularWeight | ~170kDaobserved |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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