密理博/MAB1407P |抗巨噬细胞/粒细胞抗体，克隆OX-41/MAB1407P/100µ；G
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB1407P |
| Replaces | MAB1407 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-Macrophages/GranulocytesAntibody,cloneOX-41 |
| AlternateNames |
|
| BackgroundInformation | MacrophagesandgranulocytesexpressSignalregulatoryprotein(SIRP),whichisatransmembraneglycoproteininvolvedinthedownregulationoftyrosinekinasereceptorsignaltransductioninducedbycelladhesion,growthfactorsorinsulin.Theyareimmunoglobulin-likecellsurfacereceptorforCD47.ByCD47bindingthereisanegativeregulationofphagocytosis,mastcellactivationanddendriticcellactivationthatpreventsmaturationofimmaturedendriticcellsandinhibitscytokineproductionbymaturedendriticcells. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgG2ainbuffercontaining0.09%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor6monthsat2-8°Cinundilutedaliquotsfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Ratperitonealmacrophages. |
| Clone | OX-41 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | MAB1407PrecognizesratSIRP(Signalregulatoryprotein),whichisexpressedselectivelybymyeloidcellsandbyneurons.ThismonoclonalbindstoadifferentepitopeonSIRPthanED9.ItdoesnotblocktheinteractionofCD172aandCD47. Labelsmostmacrophagesincludingresidentperitoneal,alveolarandactivatedmacrophages.Recognitionofothermacrophagesislimitedtoonlyoccasionalkupffercells.Inadditionitlabelsgranulocytesandapopulationofdendriticcells.Italsolabelsbrainextensively. |
| Isotype | IgG2a |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Human.Expectedtocross-reactwithratandmouse. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgeneisamemberofthesignal-regulatory-protein(SIRP)family,andalsobelongstotheimmunoglobulinsuperfamily.SIRPfamilymembersarereceptor-typetransmembraneglycoproteinsknowntobeinvolvedinthenegativeregulationofreceptortyrosinekinase-coupledsignalingprocesses.Thisproteincanbephosphorylatedbytyrosinekinases.Thephospho-tyrosineresiduesofthisPTPhavebeenshowntorecruitSH2domaincontainingtyrosinephosphatases(PTP),andserveassubstratesofPTPs.Thisproteinwasfoundtoparticipateinsignaltransductionmediatedbyvariousgrowthfactorreceptors.CD47hasbeendemonstratedtobealigandforthisreceptorprotein.ThisgeneanditsproductshareveryhighsimilaritywithseveralothermembersoftheSIRPfamily.Theserelatedgenesarelocatedincloseproximitytoeachotheronchromosome20p13.Multiplealternativelysplicedtranscriptvariantshavebeendeterminedforthisgene.[providedbyRefSeq] |
| GeneSymbol |
|
| PurificationMethod | ImmunoAffinityPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P78324#Immunoglobulin-likecellsurfacereceptorforCD47.ActsasdockingproteinandinducestranslocationofPTPN6,PTPN11andotherbindingpartnersfromthecytosoltotheplasmamembrane.Supportsadhesionofcerebellarneurons,neuriteoutgrowthandglialcellattachment.Mayplayakeyroleinintracellularsignalingduringsynaptogenesisandinsynapticfunction(Bysimilarity).Involvedinthenegativeregulationofreceptortyrosinekinase-coupledcellularresponsesinducedbycelladhesion,growthfactorsorinsulin.Mediatesnegativeregulationofphagocytosis,mastcellactivationanddendriticcellactivation.CD47bindingpreventsmaturationofimmaturedendriticcellsandinhibitscytokineproductionbymaturedendriticcells. SIZE:503aminoacids;54813Da SUBUNIT:BindsPTPN11whentyrosine-phosphorylated,exceptinmacrophages,whereitprimarilybindsPTPN6.BindsGRB2invitro.BindsFGR(Bysimilarity).BindsJAK2irrespectiveofitsphosphorylationstatusandformsastablecomplex.BindsSCAP1and/orSCAP2.TheresultingcomplexrecruitsFYB.BindsPTK2B. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Ubiquitous.Highlyexpressedinbrain.Detectedonmyeloidcells,butnotT-cells.Detectedatlowerlevelsinheart,placenta,lung,testis,ovary,colon,liver,smallintestine,prostate,spleen,kidney,skeletalmuscleandpancreas. PTM:N-glycosylated.&PhosphorylatedontyrosineresiduesinresponsetostimulationwithEGF,growthhormone,insulinandPDGF.DephosphorylatedbyPTPN11. SIMILARITY:SwissProt:P78324##Contains2Ig-likeC1-type(immunoglobulin-like)domains.&Contains1Ig-likeV-type(immunoglobulin-like)domain |
| MolecularWeight | 56kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
联络我们
