密理博/AB5486 |抗巨噬细胞清道夫受体1型抗体/AB5486/200µ；L
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB5486 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-MacrophageScavengerReceptorType1Antibody |
| AlternateNames |
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| BackgroundInformation | Macrophagescavengerreceptors(MSR)aremembraneglycoproteinsthatmediatetherecognitionanduptakeofawidevarietyofnegativelychargedmacromolecules.TherearetwotypesofthesereceptorsthatdifferintheC-terminalregion.MSRhasakeyroleinscavengingavarietyofmacromolecules,includingmodifiedlipoproteins,advancedglycationend(AGEs)productsandamyloidb-protein(Abeta).WhilethenormalroleofMSRisassociatedwithcelladhesionandhostdefensemechanisms,italsohasbeenimplicatedinthedevelopmentofatherosclerosisandAbdepositioninAlzheimer"sdisease(AD).Theobservationthatthe4alleleoftheapolipoproteinEgeneisassociatedwithanincreasedriskforADhasleadtotheinvestigationoflipoproteinmetabolisminthebrainofADpatients.ThetypeIMSRhasbeenfoundtobeexpressedonmicrogliaandMatocells,butnotastrocytesorneurons.InADbrain,MSRtypeIisstronglyexpressedbymicrogliacellsthatareassociatedwithsenileplaques.BecausethesenileplaquescontainAGEs,whichareasourceoffreerADIcalsthatcouldresultinoxidativedamagetothebrain,MSRmayhavearoleinmediatingtheendocytosisofAGEs. |
| ProductInformation | |
|---|---|
| Format | Serum |
| Presentation | Goatserum.Liquidcontaining0.01%thimerosal. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cinundilutedaliquotsforupto12months.Avoidrepeatedfreeze/thawcycles. |
| Applications | |
|---|---|
| Application | DetectMacrophageScavengerReceptorType1usingthisAnti-MacrophageScavengerReceptorType1AntibodyvalidatedforuseinELISA,WB,IH(P). |
| KeyApplications |
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| ApplicationNotes | Immunohistochemistry:1:200onparaffinembedded,formalinfixedhumanbrain. Westernblot:1:2,000 ELISAagainstimmunogenpeptide:1:97,000 Optimalworkingdilutionsmustbedeterminedbytheenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Syntheticpeptidethatcorrespondstoaminoacids325-342oftheC-terminusofthehumanMSRtypeI. |
| Host | Goat |
| Specificity | SpecificforhumanmacrophagescavengerreceptortypeI(MSRtypeI).Thisantibodyimmunolabelsamyloidplaquesinformalin-fixedparaffinsectionsfromAlzheimer"sDisease(AD)brain. |
| SpeciesReactivity |
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| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThisgeneencodestheclassAmacrophagescavengerreceptors,whichincludethreedifferenttypes(1,2,3)generatedbyalternativesplicingofthisgene.Thesereceptorsorisoformsaremacrophage-specifictrimericintegralmembraneglycoproteinsandhavebeenimplicatedinmanymacrophage-associatedphysiologicalandpathologicalprocessesincludingatherosclerosis,Alzheimer"sdisease,andhostdefense.Theisoformstype1andtype2arefunctionalreceptorsandareabletomediatetheendocytosisofmodifiedlowdensitylipoproteins(LDLs).Theisoformtype3doesnotinternalizemodifiedLDL(acetyl-LDL)despitehavingthedomainshowntomediatethisfunctioninthetypes1and2isoforms.Ithasanalteredintracellularprocessingandistrappedwithintheendoplasmicreticulum,makingitunabletoperformendocytosis.Theisoformtype3caninhibitthefunctionofisoformstype1andtype2whenco-expressed,indicatingadominantnegativeeffectandsuggestingamechanismforregulationofscavengerreceptoractivityinmacrophages. |
| GeneSymbol |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P21757#Membraneglycoproteinsimplicatedinthepathologicdepositionofcholesterolinarterialwallsduringatherogenesis.Twotypesofreceptorsubunitsexist.Thesereceptorsmediatetheendocytosisofadiversegroupofmacromolecules,includingmodifiedlowdensitylipoproteins(LDL). SIZE:451aminoacids;49762Da SUBUNIT:Homotrimer. SUBCELLULARLOCATION:Membrane;Single-passtypeIImembraneprotein. SIMILARITY:SwissProt:P21757##Contains1collagen-likedomain.&Contains1SRCRdomain. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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