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Millipore/ABS90 | Anti-Notch 1 Antibody, extracellular/ABS90/100 µL
Millipore/ABS90 | Anti-Notch 1 Antibody, extracellular/ABS90/100 µL
市场价：
¥5340.00
美元价：
3204.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | ABS90 |
| Description | Anti-Notch1Antibody,extracellular |
| AlternateNames |
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| BackgroundInformation | Thenotchgenebelongstoafamilyofepidermalgrowthfactor(EGF)likehomeoticgenes,whichencodetransmembraneproteinswithavariablenumberofcysteine-richEGF-likerepeatsintheextracellularregion.Fournotchgeneshavebeendescribedinmammals,whichincludenotch-1.notch-2,notch-3,andnotch-4(Int-3),whichhavebeenimplicatedinthedifferentiationofthenervoussystemandotherstructures.TheEGF-likeproteinsDeltaandSerratehavebeenidentifiedasligandsofnotch-1.Maturenotchproteinsareheterodimericreceptorsderivedfromthecleavageofnotchpre-proteinsintoanextracellularsubunit(NEC)containingmultipleEGF-likerepeatsandatransmembranesubunitincludingintracellularregion(Ntm). |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | Purifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4,150mMNaCl)with0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | GST-taggedrecombinantproteincorrespondingtotheextracellulardomainofratNotch1. |
| Epitope | Extracellulardomain |
| Host | Rabbit |
| Specificity | ThisantibodyrecognizesNotch1. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Demonstratedtoreactwithhumanandrat.Expectedtoreactwithmouse(97%sequencehomology),chimpanzee(92%sequencehomology)andcanine(91%sequencehomology). |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Transmembranereceptor;involvedincell-cellinteractionsimportantfordevelopmentandpatternformation[RGD]. |
| GeneSymbol |
|
| PurificationMethod | AffinityPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Functionsasareceptorformembrane-boundligandsJagged1,Jagged2andDelta1toregulatecell-fatedetermination.Uponligandactivationthroughthereleasednotchintracellulardomain(NICD)itformsatranscriptionalactivatorcomplexwithRBP-Jkappaandactivatesgenesoftheenhancerofsplitlocus.Affectstheimplementationofdifferentiation,proliferationandapoptoticprograms.MaybeimportantforfolliculardifferentiationandpossIBLycellfateselectionwithinthefollicle.Duringcerebellardevelopment,mayfunctionasareceptorforneuronalDNERandmaybeinvolvedinthedifferentiationofBergmannglia(Bysimilarity).ActsinstructivelytocontrolthecellfatedeterminationofCNSmultipotentProgenitorcells,resultinginastroglialinductionandneuron/oligodendrocytesuppression. SUBUNITSTRUCTURE:HeterodimerofaC-terminalfragmentN(TM)andanN-terminalfragmentN(EC)whichareprobablylinkedbydisulfidebonds.InteractswithDNER,DTX1,DTX2andRBPSUH.AlsointeractswithMAML1,MAML2andMAML3whichactastranscriptionalcoactivatorsforNOTCH1(Bysimilarity). SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein(Bysimilarity). Notch1intracellulardomain:Nucleus(Bysimilarity).Note:FollowingproteolyticalprocessingNICDistranslocatedtothenucleus(Bysimilarity). TISSUESPECIFICITY:Expressedinthebrain,kidneyandspleen.Expressedinpostnatalcentralnervoussystem(CNS)germinalzonesand,inearlypostnatallife,withinnumerouscellsthroughouttheCNS.Foundinbothsubventricularandventriculargerminalzones. DEVELOPMENTALSTAGE:Intheembryo,highestlevelsoccurbetweendays12and14anddecreaserapidlytomuchlowerlevelsintheadult. PTM:Synthesizedintheendoplasmicreticulumasaninactiveformwhichisproteolyticallycleavedbyafurin-likeconvertaseinthetrans-Golginetworkbeforeitreachestheplasmamembranetoyieldanactive,ligand-accessibleform.CleavageresultsinaC-terminalfragmentN(TM)andaN-terminalfragmentN(EC).Followingligandbinding,itiscleavedbyTNF-alphaconvertingenzyme(TACE)toyieldamembrane-associatedintermediatefragmentcallednotchextracellulartruncation(NEXT).Thisfragmentisthencleavedbypresenilindependentgamma-secretasetoreleaseanotch-derivedpeptidecontainingtheintracellulardomain(NICD)fromthemembrane(Bysimilarity). Phosphorylated(Bysimilarity). O-glycosylatedontheEGF-likedomains.ContainsbothO-linkedfucoseandO-linkedglucose(Bysimilarity). SEQUENCESIMILARITIES:BelongstotheNOTCHfamily. Contains5ANKrepeats. Contains36EGF-likedomains. Contains3LNR(Lin/Notch)repeats. |
| MolecularWeight | ~260kDaobserved.Notch1,extracellulariscalculatedat~183kDa. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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