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当前位置: 首页 > 产品中心 > Functional_antibody > 微孔/ABC36 |抗豌豆-15抗体/ABC36/100µ;G
商品详细微孔/ABC36 |抗豌豆-15抗体/ABC36/100µ;G
微孔/ABC36 |抗豌豆-15抗体/ABC36/100µ;G
微孔/ABC36 |抗豌豆-15抗体/ABC36/100µ;G
商品编号: ABC36
品牌: 密理博
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberABC36
DescriptionAnti-PEA-15Antibody
AlternateNames
  • AstrocyticphosphoproteinPEA-15
  • 15kDaphosphoproteinenrichedinastrocytes
  • Phosphoproteinenrichedindiabetes
  • PED
BackgroundInformationPEA-15isa15kDacytoplasmicproteinwhichisabundantlyexpressedinastrocytes,althoughithasbeendetectedinavarietyofothercellsincludingthoseoftheheartandmuscle.ItmaybephosphorylatedonSer104byproteinkinaseCandonSer116byCAMKII,inacalcium-dependentmanner,inresponsetovarioushormonesandneurotransmitters.PEA-15alsocontainsanN-terminaldeatheffectordomain(DED)whichischaracteristicofproteinsthatregulateapoptosis.PreviousstudieshavereportedthatitinhibitsapoptosisinducedbythesignalingofTNFαinastrocytes.However,itisbecomingincreasinglyclearthatPEA-15isamultifunctionalproteinaffectingdiversecellularprocesses,possIBLybyitsmodulationoftheMAPkinasesignalingpathway.PreviousstudieshavedemonstratedthatPEA-15bindstoERKkinaseinthecytoplasm,andpreventstheactivationandnucleartranslocationofERK.Consequently,PEA-15blockstranscriptionaleventsandcellularprocessesmediatedbyERKanditsnucleartargetElk-1.
ProductInformation
FormatPurified
Control
  • HEK293celllysate
PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
StorageandShippingInformation
StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
Applications
ApplicationThisPEA-15antibodyisvalidatedforuseinWB&IHCforthedetectionofthePEA-15protein.
KeyApplications
  • WesternBlotting
  • Immunohistochemistry
ApplicationNotesWesternBlotAnalysis:2µg/mLfromarepresentativelotdetectedPEA-15on10µgofHeLa,L6,andNIH/3T3celllysates.

ImmunohistochemistryAnalysis:A1:1,000-4,000dilutionfromarepresentativelotdetectedPEA-15inmousecerebellum,humanbrain,andhuamncardiacmuscletissues.
BIOLOGicalInformation
ImmunogenGST-taggedrecombinantproteincorrespondingtohumanPEA-15.
ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
HostRabbit
SpeciesReactivity
  • Human
  • Mouse
  • Rat
AntibodyTypePolyclonalAntibody
EntrezGeneNumber
GeneSymbol
  • PEA15
PurificationMethodProteinAPurfied
UniProtNumber
MolecularWeight~17kDaobserved.Anuncharacterizedbandappearsat~32and~260kDainsomelysates.
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。