密理博/AB5702 |抗HES-1抗体/AB5702/100µ；G
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB5702 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-HES-1Antibody |
| AlternateNames |
|
| BackgroundInformation | Hes1isatranscriptionalrepressorofgenesthatrequireabHLHproteinfortheirtranscription.ItmayactasanegativeregulatorofmyogenesisbyinhibitingthefunctionsofMYOD1andASH1.Hes1isexpressedindevelopingneuroectodermalandendodermalendocrinetissues,andHes1deficientembryosshowseveredefectsinneuronaldevelopment,aswellaspancreatichypoplasia. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | Purifiedrabbitpolyclonalinbuffercontainingasolutionof50%saturatedammoniumsulfateandPBScontainingnopreservatives. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-80ºCfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Syntheticpeptide. |
| Host | Rabbit |
| Specificity | RecognizesHES-1(Hairyfamily),aHelix-loop-helixclassoftranscriptionfactor. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Humanandrodent.Reactivitywithotherspecieshasnotbeenconfirmed. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisproteinbelongstothebasichelix-loop-helixfamilyoftranscriptionfactors.ItisatranscriptionalrepressorofgenesthatrequireabHLHproteinfortheirtranscription.TheproteinhasaparticulartypeofbasicdomainthatcontainsahelixinterruptingproteinthatbindstotheN-boxratherthanthecanonicalE-box. |
| GeneSymbol |
|
| PurificationMethod | ImmunoAffinityPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q14469#TranscriptionalrepressorofgenesthatrequireabHLHproteinfortheirtranscription.MayactasanegativeregulatorofmyogenesisbyinhibitingthefunctionsofMYOD1andASH1(Bysimilarity). SIZE:280aminoacids;29541Da SUBUNIT:Transcriptionrepressionrequiresformationofacomplexwithacorepressorprotein(Groucho)suchasTLE2(Bysimilarity).InteractswithSIRT1. SUBCELLULARLOCATION:Nucleus. DOMAIN:SwissProt:Q14469Hasaparticulartypeofbasicdomain(presenceofahelix-interruptingproline)thatbindstotheN-box(CACNAG),ratherthanthecanonicalE-box(CANNTG).&TheC-terminalWRPWmotifisatranscriptionalrepressiondomainnecessaryfortheinteractionwithGroucho,atranscriptionalcorepressorrecruitedtospecifictargetDNAbyHairy-relatedproteins. SIMILARITY:Contains1basichelix-loop-helix(bHLH)domain.&Contains1Orangedomain....hide»seemore» |
| MolecularWeight | 29kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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