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Millipore/04-1046 | Anti-Notch1 (Cytoplasmic) Antibody, clone EP1238Y, Rabbit | 04-1046/04-1046/100 µL
Millipore/04-1046 | Anti-Notch1 (Cytoplasmic) Antibody, clone EP1238Y, Rabbit | 04-1046/04-1046/100 µL
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 04-1046 |
| Description | Anti-Notch1(Cytoplasmic)Antibody,cloneEP1238Y,Rabbit|04-1046 |
| AlternateNames |
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| BackgroundInformation | NotchisthereceptorforDeltaandJaggedligands,whichcauseproteolysisofnotchtoliberatetheintracellulardomain.ThatdomaintranslocatestothenucleusandinitiatestranscriptioneventsbybindingtheDNAbindingproteinCSL.Thenotchfamilymembersareinvolvedinnumerousdifferentiationandcelllineagedeterminationsteps. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | RabbitmonoclonalIgGinbuffercontaining50mMTris-Glycine(pH7.4),0.18MNaClcontaining40%Glycerol,0.25%sodiumazide,0.25mMEDTA,25mMCitricAcid,and0.5%BSA. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt. HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptidecorrespondingtothecytoplasmicdomainofhumanNotch1 |
| Epitope | CytoplasmicDomain |
| Clone | EP1238Y |
| Host | Rabbit |
| Specificity | ThisantibodyrecognizesthecytoplasmicdomainofNotch1 |
| Isotype | IgG |
| SpeciesReactivity |
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| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThisgeneencodesamemberoftheNotchfamily.MembersofthisType1transmembraneproteinfamilysharestructuralcharacteristicsincludinganextracellulardomainconsistingofmultipleepidermalgrowthfactor-like(EGF)repeats,andanintracellulardomainconsistingofmultiple,differentdomaintypes.Notchfamilymembersplayaroleinavarietyofdevelopmentalprocessesbycontrollingcellfatedecisions.TheNotchsignalingnetworkisanevolutionarilyconservedintercellularsignalingpathwaywhichregulatesinteractionsbetweenphysicallyadjacentcells.InDrosophilia,notchinteractionwithitscell-boundligands(delta,serrate)establishesanintercellularsignalingpathwaythatplaysakeyroleindevelopment.Homologuesofthenotch-ligandshavealsobeenidentifiedinhuman,butpreciseinteractionsbetweentheseligandsandthehumannotchhomologuesremaintobedetermined.Thisproteiniscleavedinthetrans-Golginetwork,andpresentedonthecellsurfaceasaheterodimer.Thisproteinfunctionsasareceptorformembraneboundligands,andmayplaymultiplerolesduringdevelopment.[providedbyRefSeq] |
| GeneSymbol |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:Functionsasareceptorformembrane-boundligandsJagged1,Jagged2andDelta1toregulatecell-fatedetermination.Uponligandactivationthroughthereleasednotchintracellulardomain(NICD)itformsatranscriptionalactivatorcomplexwithRBP-Jkappaandactivatesgenesoftheenhancerofsplitlocus.Affectstheimplementationofdifferentiation,proliferationandapoptoticprograms.Maybeimportantfornormallymphocytefunction.Inalteredform,maycontributetotransformationorprogressioninsomeT-cellneoplasms.InvolvedinthematurationofbothCD4+andCD8+cellsinthethymus.MaybeimportantforfolliculardifferentiationandpossIBLycellfateselectionwithinthefollicle.Duringcerebellardevelopment,mayfunctionasareceptorforneuronalDNERandmaybeinvolvedinthedifferentiationofBergmanngliaBysimilarity. SUBUNITSTRUCTURE:HeterodimerofaC-terminalfragmentN(TM)andanN-terminalfragmentN(EC)whichareprobablylinkedbydisulfidebonds.InteractswithDNER,DTX1,DTX2andRBPSUH.AlsointeractswithMAML1,MAML2andMAML3whichactastranscriptionalcoactivatorsforNOTCH1.Ref.6Ref.7Ref.8 SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneproteinBysimilarity. Notch1intracellulardomain:NucleusBysimilarity.Note=FollowingproteolyticalprocessingNICDistranslocatedtothenucleusBysimilarity. TISSUESPECIFICTY:Infetaltissuesmostabundantinspleen,brainstemandlung.Alsopresentinmostadulttissueswhereitisfoundmainlyinlymphoidtissues. PTM:Synthesizedintheendoplasmicreticulumasaninactiveformwhichisproteolyticallycleavedbyafurin-likeconvertaseinthetrans-Golginetworkbeforeitreachestheplasmamembranetoyieldanactive,ligand-accessibleform.CleavageresultsinaC-terminalfragmentN(TM)andaN-terminalfragmentN(EC).Followingligandbinding,itiscleavedbyTNF-alphaconvertingenzyme(TACE)toyieldamembrane-associatedintermediatefragmentcallednotchextracellulartruncation(NEXT).Thisfragmentisthencleavedbypresenilindependentgamma-secretasetoreleaseanotch-derivedpeptidecontainingtheintracellulardomain(NICD)fromthemembraneBysimilarity. PhosphorylatedBysimilarity. INVOLVEMENTINDISEASE:NOTCH1truncationisassociatedwithT-cellacutelymphoblasticleukemia.Ref.13 DefectsinNOTCH1areacauseofaorticvalvedisease[MIM:109730].Thedisorderconsistsofanearlydevelopmentaldefectintheaorticvalveandalaterde-repressionofcalciumdepositionthatcausesprogressiveaorticvalvedisease.CalcificationoftheaorticvalveisthethirdleADIngcauseofheartdiseaseinadults.Theincidenceincreaseswithage,anditisoftenassociatedwithabicUSPidaorticvalvepresentin1-2%ofthepopulation. SEQUENCESIMILARITIES:BelongstotheNOTCHfamily. Contains5ANKrepeats. Contains36EGF-likedomains. Contains3LNR(Lin/Notch)repeats. |
| MolecularWeight | ~125kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
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