密理博/07-213 |抗二甲基组蛋白H4（Arg3）抗体/07-213/100µ；L
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¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 07-213 |
| BrandFamily | Upstate |
| TradeName |
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| Description | Anti-dimethyl-HistoneH4(Arg3)Antibody |
| AlternateNames |
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| BackgroundInformation | HistoneH4isoneofthe5mainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongNterminaltailH4isinvolvedwiththestructureofthenucleosomesofthe"beadsonastring"structure.AcetylationofhistoneH4occursatseveraldifferentlysinepositionsinthehistonetailandisperformedbyafamilyofenzymesknownasHistoneAcetylTransferases(HATs). |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
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| Presentation | PurifiedrabbitpolyclonalIgGinbuffercontaining70%storagebuffer0.2MTris-glycine,pH7.4,0.15MNaCl,0.05%sodiumazide,5mg/mLBSAand30%glycerol. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearatfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | BSA-conjugatedsyntheticpeptide(SG[me2R]GKGGKG-C)correspondingtoaminoacids1-9ofHistoneH4withaC-terminalcysteineaddedtofacilitateconjugation.TheimmunizingsequenceisconservedfromTetrahymenatohuman. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | RecognizesmethylatedHistoneH4(Arg3),MW10kDa.Additionof0.1%Tween®-20inwesternblotbuffersresultsinthedetectionofadditionalproteinsat17kDa(possIBLymethylatedHistoneH2a),34kDaand80kDa.SpecificitydemonstratedbyELISAusingmethylatedandunmethylatedHistoneH4peptides.TheantibodydoesnotdetectrecombinantHistoneH3purifiedfromE.coli. |
| Isotype | IgG |
| SpeciesReactivity |
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| SpeciesReactivityNote | Human.Broadspeciescross-reactivityisexpected. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Histonesarebasicnuclearproteinsthatareresponsibleforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.ThisgeneisintronlessandencodesamemberofthehistoneH4family.TranscriptsfromthisgenelackpolyAtails;instead,theycontainapalindromicterminationelement. |
| GeneSymbol |
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| Modifications |
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| PurificationMethod | ImmunoaffinityChromatography |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P62805#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. SIZE:103aminoacids;11367Da SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA. SUBCELLULARLOCATION:Nucleus. PTM:SymmetricdimethylationonArg-4bythePRDM1/PRMT5complexmayplayacrucialroleinthegerm-celllineage(Bysimilarity).&UbiquitinatedbytheCUL4-DDB-RBX1complexinresponsetoultravioletirrADIation.ThismayweakentheinteractionbetweenhistonesandDNAandfacilitateDNAaccessibilitytorepairproteins. SIMILARITY:SwissProt:P62805##BelongstothehistoneH4family. |
| MolecularWeight | 10kDa |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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