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Millipore/07-1584 | Anti-dimethyl Histone H4 (Lys20) Antibody/07-1584/100 µg
Millipore/07-1584 | Anti-dimethyl Histone H4 (Lys20) Antibody/07-1584/100 µg
市场价：
¥7800.00
美元价：
4680.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 07-1584 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-dimethylHistoneH4(Lys20)Antibody |
| AlternateNames |
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| BackgroundInformation | HistonesarehighlyconservedproteinsthatserveasthestructuralscaffoldfortheorganizationofnuclearDNAintochromatin.HistonemodificationsregulateDNAtranscription,repair,recombination,andreplication.Themostcommonlystudiedmodificationsareacetylation,phosphorylation,methylation,andubiquitination.Thesemodificationscanalterlocalchromatinarchitecture,orrecruittrans-actingfactorsthatrecognizespecifichistonemodifications(the"histonecode"hypothesis).Inmammals,H4K20methylationisoneofthemostcommonchromatinmodificationsandithasbeenimplicatedinvariousBIOLOGicalprocesses,includingheterochromatinformation,telomerefunction,imprinting,Xinactivation,DNAdamagerepairandcancerprogression.H4K20me2isthemostabundanthistonemodificationwithmorethat80%ofallhistoneH4moleculescarryingthismark.TheSuv4-20henzymesarethetwomajorhistonemethyltransferasestoinduceH4K20me2andme3states. |
| ProductInformation | |
|---|---|
| Format | Purified |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. Formaximumrecoveryofproduct,centrifugethevialpriortoremovingthecap. |
| BiologicalInformation | |
|---|---|
| Immunogen | KLH-conjugated,syntheticpeptidecontainingthesequence(AKRHR[dimethyl-K]VLRD-C),correspondingtothesequencesurroundingacetylatedlysine20ofhumanhistoneH4. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | RecognizeshistoneH4acetylatedonLys20,Mr~10kDa. |
| SpeciesReactivity |
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| SpeciesReactivityNote | Broadspeciescross-reactivityexpectedduetosequencehomology |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.ThisgeneisintronlessandencodesamemberofthehistoneH4family.TranscriptsfromthisgenelackpolyAtails;instead,theycontainapalindromicterminationelement. |
| Modifications |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA. INTERACTION: Q13547:HDAC1;NbExp=1;IntAct=EBI-302023,EBI-301834; P56524:HDAC4;NbExp=1;IntAct=EBI-302023,EBI-308629; Q9UQL6:HDAC5;NbExp=1;IntAct=EBI-302023,EBI-715576; Q9UBN7:HDAC6;NbExp=1;IntAct=EBI-302023,EBI-301697; Q9Y468:L3MBTL;NbExp=2;IntAct=EBI-302023,EBI-1265089; Q9SU94:PRMT1.1(xeno);NbExp=1;IntAct=EBI-302023,EBI-1382731; O82210:PRMT1.2(xeno);NbExp=1;IntAct=EBI-302023,EBI-1382526; Q9NQR1:SETD8;NbExp=4;IntAct=EBI-302023,EBI-1268946; SUBCELLULARLOCATION:Nucleus. PTM:AcetylationatLys-6,Lys-9,Lys-13andLys-17occursincodingregionsofthegenomebutnotinheterochromatin. PTM:CitrullinationatArg-4byPADI4impairsmethylation. PTM:MonomethylationatArg-4byPRMT1favorsacetylationatLys-9andLys-13.DemethylationisperformedbyJMJD6. PTM:Monomethylated,dimethylatedortrimethylatedatLys-21.MonomethylationisperformedbySET8.TrimethylationisperformedbySUV420H1andSUV420H2andinducesgenesilencing. PTM:UbiquitinatedbytheCUL4-DDB-RBX1complexinresponsetoultravioletirradiation.ThismayweakentheinteractionbetweenhistonesandDNAandfacilitateDNAaccessibilitytorepairproteins. PTM:Sumoylated,whichisassociatedwithtranscriptionalrepression. SIMILARITY:BelongstothehistoneH4family. |
| MolecularWeight | ~10kDa |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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