密理博/07-1570 |抗单甲基组蛋白H4（Lys20）抗体/07-1570/100µ；G
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¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 07-1570 |
| Description | Anti-monomethylHistoneH4(Lys20)Antibody |
| AlternateNames |
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| BackgroundInformation | HistonesarehighlyconservedproteinsthatserveasthestructuralscaffoldfortheorganizationofnuclearDNAintochromatin.HistonesmodificationsregulateDNAtranscription,repair,recombination,andreplication.Themostcommonlystudiedmodificationsareacetylation,phosphorylation,methylation,andubiquitination.Thesemodificationscanalterlocalchromatinarchitecture,orrecruittrans-actingfactorsthatrecognizespecifichistonemodifications(the"histonecode"hypothesis).MethylationofhistoneH4atlysine20hasbeenimplicatedintranscriptionalactivation,genesilencing,heterochromatinformation,mitosis,andDNArepair.HistoneH4isprogressivelymethylatedatLys20duringtheG(2),M,andG(1)phasesofthecellcycle,andmethylationofH4Lys20isaMarkerforheterochromatin.Inmammals,thefemaleXchromosomeiscoatedbytheXistRNA,whichiscriticalforsilencing,andismarkedmainlybymethylationofH3Lys9,H3Lys27andH4Lys20. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
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| Presentation | Purifiedfromserumbyaffinitychromatography.Suppliedat1mg/mlin0.1MTris-Glycine(pH7.4),15mMNaCl,0.05%NaN3. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20°Cfromdateofreceipt. HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugated,linearsyntheticpeptidecorrespondingtoaminoacids15-24 (AKRHR[me1K]VLRD-C)ofhumanHistoneH4. |
| Epitope | MonomethylLys20 |
| Host | Rabbit |
| Specificity | RecognizesmonomethylatedHistoneH4 (Lys20),Mr11kDa. |
| SpeciesReactivity |
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| SpeciesReactivityNote | Human.Basedonsequencehomology,broadspeciescross-reactivityisexpected |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneisintronlessandencodesamemberofthehistoneH4family.TranscriptsfromthisgenelackpolyAtailsbutinsteadcontainapalindromicterminationelement.Thisgeneisfoundinthelargehistonegeneclusteronchromosome6.[providedbyRefSeq] |
| GeneSymbol |
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| Modifications |
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| PurificationMethod | AffinityChromatography |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA SUBCELLULARLOCATION:Nucleus. PTM:AcetylationatLys-6,Lys-9,Lys-13andLys-17occursincodingregionsofthegenomebutnotinheterochromatin. PTM:CitrullinationatArg-4byPADI4impairsmethylation. PTM:MonomethylationatArg-4byPRMT1favorsacetylationatLys-9andLys-13.DemethylationisperformedbyJMJD6. PTM:Monomethylated,dimethylatedortrimethylatedatLys-21.MonomethylationisperformedbySET8.TrimethylationisperformedbySUV420H1andSUV420H2andinducesgenesilencing. PTM:UbiquitinatedbytheCUL4-DDB-RBX1complexinresponsetoultravioletirradiation.ThismayweakentheinteractionbetweenhistonesandDNAandfacilitateDNAaccessibilitytorepairproteins. PTM:Sumoylated,whichisassociatedwithtranscriptionalrepression. SIMILARITY:BelongstothehistoneH4family. |
| MolecularWeight | ~11kDa |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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