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Millipore/04-079 | Anti-trimethyl-Histone H4 (Lys20), Antibody, rabbit monoclonal/04-079/100 µL
Millipore/04-079 | Anti-trimethyl-Histone H4 (Lys20), Antibody, rabbit monoclonal/04-079/100 µL
市场价：
¥7800.00
美元价：
4680.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 04-079 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-trimethyl-HistoneH4(Lys20),Antibody,rabbitmonoclonal |
| AlternateNames |
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| BackgroundInformation | HistonesarenuclearproteinsthatformoctamericstructureswhichbindDNAtoformunitsofchromatincallednucleosomes.Thefamilyofhistones—H2A,H2B,H3,andH4—arekeyplayersingeneregulation.Theyundergoanumberofpost-translationalmodifications(PTM)inresponsetovariousstimuli,includingphosphorylationonserineandthreonineresiduesandmethylationonlysineresidues.PTMsproduceconfiguralchangesinhistoneproteinsthatmayinducenucleosomeremodelingandexposeorhideDNAsequencesfromtranscriptionalcomplexes.HistoneH4lysine20(H4K20)mayundergomono-,di-,ortrimethylation,whichiscatalyzedbythemethyltransferasePR-Set7(Set8orKMT5a).MethylatedH4K20playsaroleinregulatingDNAdamageresponses,mitosis,DNAreplication,andgeneexpression.TrimethylationofH4K20contributestogenesilencing,andisamarkoftherepressiveheterochromatinstate. |
| ProductInformation | |
|---|---|
| Format | CultureSupernatant |
| Presentation | 100μLofrabbitmonoclonalIgGcellculturesupernatantin0.1%sodiumazide |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | 2yearsat-20°Cfromdateofshipment |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | PeptidecorrespondingtohumanHistoneH4containingthesequence[HRmethKVL]onwhichlysine20istrimethylated. |
| Host | Rabbit |
| Specificity | RecognizesHistoneH4whentrimethylatedonLys20. |
| Isotype | IgG |
| SpeciesReactivity |
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| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | HistonesarenuclearproteinsthatformoctamericstructureswhichbindDNAtoformunitsofchromatincallednucleosomes.Thefamilyofhistones—H2A,H2B,H3,andH4—arekeyplayersingeneregulation.Theyundergoanumberofpost-translationalmodifications(PTM)inresponsetovariousstimuli,includingphosphorylationonserineandthreonineresiduesandmethylationonlysineresidues.PTMsproduceconfiguralchangesinhistoneproteinsthatmayinducenucleosomeremodelingandexposeorhideDNAsequencesfromtranscriptionalcomplexes.HistoneH4lysine20(H4K20)mayundergomono-,di-,ortrimethylation,whichiscatalyzedbythemethyltransferasePR-Set7(Set8orKMT5a).MethylatedH4K20playsaroleinregulatingDNAdamageresponses,mitosis,DNAreplication,andgeneexpression.TrimethylationofH4K20contributestogenesilencing,andisamarkoftherepressiveheterochromatinstate. |
| GeneSymbol |
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| Modifications |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P62805#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. SIZE:103aminoacids;11367Da SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA. SUBCELLULARLOCATION:Nucleus. PTM:SymmetricdimethylationonArg-4bythePRDM1/PRMT5complexmayplayacrucialroleinthegerm-celllineage(Bysimilarity).&UbiquitinatedbytheCUL4-DDB-RBX1complexinresponsetoultravioletirrADIation.ThismayweakentheinteractionbetweenhistonesandDNAandfacilitateDNAaccessibilitytorepairproteins. SIMILARITY:SwissProt:P62805##BelongstothehistoneH4family. |
| MolecularWeight | 11kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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