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Millipore/05-1232 | Anti-acetyl Histone H4 (Lys16) Antibody, clone 4E10.2/05-1232/100 µg
Millipore/05-1232 | Anti-acetyl Histone H4 (Lys16) Antibody, clone 4E10.2/05-1232/100 µg
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 05-1232 |
| TradeName |
|
| Description | Anti-acetylHistoneH4(Lys16)Antibody,clone4E10.2 |
| AlternateNames |
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| BackgroundInformation | HistonesarehighlyconservedproteinsthatserveasthestructuralscaffoldfortheorganizationofnuclearDNAintochromatin.HistonemodificationsregulateDNAtranscription,repair,recombination,andreplication.Themostcommonlystudiedmodificationsareacetylation,phosphorylation,methylation,andubiquitination.Thesemodificationscanalterlocalchromatinarchitecture,orrecruittrans-actingfactorsthatrecognizespecifichistonemodifications(the"histonecode"hypothesis).GloballossofacetylationatLys16isacommonhallmarkofhumantumorcells,suggestingaroleforacetylatedLys16inpreventingcelltransformation.Moreover,Lys16istheonlyhistonemarkthathasbeendirectlylinkedtochromatinrefoldingandmaintainenceofchromatinstructure.TheSir3proteinhelpsformtelomericheterochromatinbyinteractingwithhypoacetylatedhistoneH4Lys16whiletheMYST-likeacetyltransferaseSas2pisrequiredfortheacetylationH4-Lys16ineuchromatin. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
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| Presentation | PurifiedfromascitesbyproteinGchromatography.Suppliedat1mg/mlinPBS,0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. Formaximumrecoveryofproduct,centrifugethevialpriortoremovingthecap. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugated,syntheticpeptidecontainingthesequence(GKGGA[acetyl-K]RHRKC,correspondingtothesequencesurroundingacetylatedlysine16ofhumanhistoneH4. |
| Epitope | AcetylLys16 |
| Clone | 4E10.2 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | RecognizeshistoneH4acetylatedonLys16,Mr11kDa. |
| Isotype | IgG1κ |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Basedonsequencehomology,broadspeciescross-reactivityisexpected. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.ThisgeneisintronlessandencodesamemberofthehistoneH4family.TranscriptsfromthisgenelackpolyAtails;instead,theycontainapalindromicterminationelement.[providedbyRefSeq]. |
| Modifications |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. Subunitstructure:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA. Subcellularlocation:Nucleus. Post-translationalmodification:AcetylationatLys-6,Lys-9,Lys-13andLys-17occursincodingregionsofthegenomebutnotinheterochromatin. |
| MolecularWeight | ~11kDa |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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