Millipore/MABE15 |抗组蛋白H2B抗体，克隆EP957Y，兔单克隆/MABE15/100µ；L
市场价：
¥5340.00
美元价：
3204.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MABE15 |
| Description | Anti-HistoneH2BAntibody,cloneEP957Y,rabbitmonoclonal |
| AlternateNames |
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| BackgroundInformation | Changesinchromatinstructureplayalargeroleintheregulationoftranscriptionineukaryotes(1).Thenucleosomeistheprimarybuildingblockofchromatin,andismadeupoffourcorehistoneproteins(H2A,H2B,H3andH4)(2).Acetylationofcorehistonesregulatesgeneexpression(2).HistoneH2Bisprimarilyacetylatedatlysines5,12,15,and20(3).UbiquitylationofHistoneH2Batlysine123byRad6hasbeenimplicatedintranscriptionalactivationandlysinemethylationonhistoneH3(4).HistoneH2BphosphorylationatSer10(foryeast)andSer14(formammaliancells)hasbeenlinkedtoregulationofapoptosisandmeiosis(5). |
| ProductInformation | |
|---|---|
| Format | Unpurified |
| Control |
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| Presentation | Rabbitmonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaCl,40%Glycerol,0.01%sodiumazideand0.05%BSA. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20°Cfromdateofreceipt. HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptidecorrespondingtohumanHistoneH2B. |
| Clone | EP957Y |
| Host | Rabbit |
| Specificity | ThisantibodyrecognizesHistoneH2B. |
| Isotype | IgG |
| SpeciesReactivity |
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| SpeciesReactivityNote | Proventoreactwithhuman,mouse,andrat. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
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| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstability.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. Hasbroadantibacterialactivity.Maycontributetotheformationofthefunctionalantimicrobialbarrierofthecolonicepithelium,andtothebactericidalactivityofamnioticfluid. SUBUNITSTRUCTURE:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA. SUBCELLULARLOCATION:Nucleus.Chromosome. PTM:MonoubiquitinationofLys-121bytheRNF20/40complexgivesaspecifictagforepigenetictranscriptionalactivationandisalsoprerequisiteforhistoneH3"Lys-4"and"Lys-79"methylation.ItalsofunctionscooperativelywiththeFACTdimertostimulateelongationbyRNApolymeraseII. PhosphorylatedonSer-15bySTK4/MST1duringapoptosis;whichfacilitatesapoptoticchromatincondensation.AlsophosphorylatedonSer-15inresponsetoDNAdoublestrandbreaks(DSBs),andincorrelationwithsomatichypermutationandimmunoglobulinclass-switchrecombination. SEQUENCESIMILARITIES:BelongstothehistoneH2Bfamily. |
| MolecularWeight | ~14kDaobserved |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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