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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/07-564 | Anti-acetyl-Histone H2B (Lys120) Antibody/07-564/100 µL
商品详细Millipore/07-564 | Anti-acetyl-Histone H2B (Lys120) Antibody/07-564/100 µL
Millipore/07-564 | Anti-acetyl-Histone H2B (Lys120) Antibody/07-564/100 µL
Millipore/07-564 | Anti-acetyl-Histone H2B (Lys120) Antibody/07-564/100 µL
商品编号: 07-564
品牌: 密理博
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
Catalogue Number07-564
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-acetyl-Histone H2B (Lys120) Antibody
Alternate Names
  • H2BK120Ac
  • Histone H2B (acetyl K120)
Product Information
FormatAffinity Purified
Presentation50mM Tris-glycine, pH 8.0 containing 0.05% sodium azide and 30% glycerol
Storage and Shipping Information
Storage Conditions1 year at -20°C
Applications
ApplicationUse Anti-acetyl-Histone H2B (Lys120) Antibody (Rabbit Polyclonal Antibody) validated in DB, WB, PIA to detect acetyl-Histone H2B (Lys120) also known as H2BK120Ac, Histone H2B (acetyl K120).
Key Applications
  • Dot Blot
  • Western Blotting
  • Peptide Inhibition Assay
Biological Information
ImmunogenPeptide containing the sequence VTacKYT in which acK corresponds to acetylated lysine 120 of human histone H2B.
HostRabbit
SpecificityHistone H2B acetylated on lysine 120
IsotypeIgG
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.
Gene Symbol
  • HIST3H2BB
Modifications
  • Acetylation
Purification MethodImmunoAffinity Purified
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q8N257 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
SIZE: 126 amino acids; 13908 Da
SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
SUBCELLULAR LOCATION: Nucleus.
PTM: Monoubiquitination of Lys-121 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. & Phosphorylated on Ser-15 by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class- switch recombination.
SIMILARITY: SwissProt: Q8N257 ## Belongs to the histone H2B family.
Molecular Weight~15kDa
Physicochemical Information
Dimensions
Materials Information
Materials Information
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。