Millipore/07-371 |抗组蛋白H2B抗体/07-371/200µ；G
市场价：
¥7800.00
美元价：
4680.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 07-371 |
| Replaces | MABE15 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-HistoneH2BAntibody |
| AlternateNames |
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| BackgroundInformation | HistoneH2Btype3-B(UniProt:Q8N257;alsoknownasH2Btype12)isencodedbytheHIST3H2BBgene(GeneID:128312)inhuman.HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofchromatinineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichDNAiswrappedinrepeatingunits,callednucleosomes,whichlimitsDNAaccessibilitytothecellularmachineries,whichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.HistoneH2Bisoneofthemainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongNterminaltail,H2Bisinvolvedwiththestructureofthenucleosomesofthe"beadsonastring"structure.HistoneH2BcanbemonoubiquitinatedonLysine123byRAD6/UBC2-BRE1complextoformH2BK123Ub1complexthatgivesaspecifictagforepigenetictranscriptionalactivationandisalsoaprerequisiteforH3K4meandH3K79meformation.H2BK123ub1isreportedtomodulatestheformationofdouble-strandbreaksduringmeiosisandisarequiredforDNA-damagecheckpointactivation.HistoneH2BisphosphorylatedbySTE20toformH2BS10phduringprogressionthroughmeioticprophaseandmaybecorrelatedwithchromosomecondensation.HistoneH2BcanundergoacetylationbyGCN5,acomponentoftheSAGAcomplex,toformH2BK11acandH2BK16ac.AcetylationofN-terminallysinesandparticularlyformationofH2BK11acK16achasapositiveeffectontranscription. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | Purifiedrabbitpolyclonalantibodyinbuffercontaining0.02Mphosphatebuffer,pH7.6,0.25MNaCl,with0.1%sodiumazideand30%glycerol. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugatedlinearpeptidecorrespondingto9aminoacidsfromtheC-terminusofhumanHistoneH2Btype3-B. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | ThisrabbitpolyclonalantibodydetectsHistoneH2Binhumanandchicken.Ittargetsanepitopewithin9aminoacidsfromtheC-terminusregion. |
| Isotype | IgG |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Human,Chicken.PredictedtoreactwithYeast,Xenopusbasedon100%sequencehomology. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Histonesarebasicnuclearproteinsthatareresponsibleforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.ThisgeneisintronlessandencodesamemberofthehistoneH2Bfamily.Transcriptsfromthisgenecontainapalindromicterminationelement. |
| GeneSymbol |
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| PurificationMethod | ProteinAchromatography |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q8N257#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstability.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. SIZE:126aminoacids;13908Da SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA. SUBCELLULARLOCATION:Nucleus. PTM:MonoubiquitinationofLys-121bytheRNF20/40complexgivesaspecifictagforepigenetictranscriptionalactivationandisalsoprerequisiteforhistoneH3"Lys-4"and"Lys-79"methylation.ItalsofunctionscooperativelywiththeFACTdimertostimulateelongationbyRNApolymeraseII.&PhosphorylatedonSer-15bySTK4/MST1duringapoptosis;whichfacilitatesapoptoticchromatincondensation.AlsophosphorylatedonSer-15inresponsetoDNAdoublestrandbreaks(DSBs),andincorrelationwithsomatichypermutationandimmunoglobulinclass-switchrecombination. SIMILARITY:SwissProt:Q8N257##BelongstothehistoneH2Bfamily. |
| MolecularWeight | ~17kDaobserved;13.91kDacalculated.Uncharacterizedbandsmaybeobservedinsomelysate(s). |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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