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Millipore/IHCR2023-6 | IHC Select® Anti-CD79a Antibody, prediluted, clone JCB117/IHCR2023-6/6 mL
Millipore/IHCR2023-6 | IHC Select® Anti-CD79a Antibody, prediluted, clone JCB117/IHCR2023-6/6 mL
商品编号：
IHCR2023-6
品牌：
密理博
市场价：
¥4920.00
美元价：
2952.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | IHCR2023-6 |
| TradeName |
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| Description | IHCSelect®Anti-CD79aAntibody,prediluted,cloneJCB117 |
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | Monoclonalmouseantibodysuppliedinliquidformatastissueculturesupernatant,dilutedinPBS,pH7.2withstABIlizers,0.2%Tween20,and0.1%ProClin300aspreservative. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat2-8°C.Refertovialforexpirationdating. |
| BIOLOGicalInformation | |
|---|---|
| Clone | JCB117 |
| Host | Mouse |
| Specificity | Bcellantigenreceptorcomplex.TheantibodyreactswithcellsinBcellareasinlymphoidtissue,andwithscatteredcellsinmanyothertissues. |
| Isotype | IgG1κ |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | TheBlymphocyteantigenreceptorisamultimericcomplexthatincludestheantigen-specificcomponent,surfaceimmunoglobulin(Ig).SurfaceIgnon-covalentlyassociateswithtwootherproteins,Ig-alphaandIg-beta,whicharenecessaryforexpressionandfunctionoftheB-cellantigenreceptor.ThisgeneencodestheIg-alphaproteinoftheB-cellantigencomponent.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeendescribed. |
| GeneSymbol |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P11912#RequiredincooperationwithCD79BforinitiationofthesignaltransductioncascadeactivatedbybindingofantigentotheB-cellantigenreceptorcomplex(BCR)whichleadstointernalizationofthecomplex,traffickingtolateendosomesandantigenpresentation.AlsorequiredforBCRsurfaceexpressionandforefficientdifferentiationofpro-andpre-B-cells.StimulatesSYKautophosphorylationandactivation.BindstoBLNK,bringingBLNKintoproximitywithSYKandallowingSYKtophosphorylateBLNK.AlsointeractswithandincreasesactivityofsomeSrc-familytyrosinekinases.RepressesBCRsignalingduringdevelopmentofimmatureBcells. SIZE:226aminoacids;25038Da SUBUNIT:Heterodimerofalphaandbetachains;disulfide-linked.PartoftheB-cellantigenreceptorcomplexwherethealpha/betachainheterodimerisnon-covalentlyassociatedwithanantigen-specificmembrane-boundsurfaceimmunoglobulinoftwoheavychainsandtwolightchains.InteractsthroughitsphosphorylatedITAMdomainwiththeSH2domainsofSYKwhichstimulatesSYKautophosphorylationandactivation.Alsointeracts,whenphosphorylatedonTyr-210,withtheSH2domainofBLNK/SLP65,bringingBLNKintoproximitywithSYKandallowingSYKtophosphorylateBLNKwhichisnecessaryfortraffickingoftheBCRtolateendosomes.InteractswithSrc-familytyrosinekinasesincludingFYNandLYN,increasingtheiractivity(Bysimilarity). SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.Note=Followingantigenbinding,theBCRhasbeenshowntotranslocatefromdetergent-solubleregionsofthecellmembranetolipidraftsalthoughsignaltransductionthroughthecomplexcanalsooccuroutsidelipidrafts(Bysimilarity). TISSUESPECIFICITY:B-cells. PTM:Phosphorylatedontyrosine,serineandthreonineresiduesuponB-cellactivation.PhosphorylationoftyrosineresiduesbySrc-familykinasesisanearlyandessentialfeatureoftheBCRsignalingcascade.ThephosphorylatedtyrosinesserveasdockingsitesforSH2-domaincontainingkinases,leADIngtotheiractivationwhichinturnleadstophosphorylationofdownstreamtargets.Phosphorylationofserineandthreonineresiduesmaypreventsubsequenttyrosinephosphorylation. DISEASE:SwissProt:P11912#DefectsinCD79Aareacauseofnon-Brutontypeagammaglobulinemia[MIM:601495].AgammaglobulinemiaisanimmunodeficiencydiseasewhichresultsindevelopmentaldefectsinthematurationpathwayofB-cells.Twodifferentmutations,oneatthesplicedonorsiteofintron2andtheotheratthespliceacceptorsiteforexon3,havebeenidentified.Bothmutationsgiverisetoatruncatedprotein. SIMILARITY:SwissProt:P11912##Contains1Ig-likeC2-type(immunoglobulin-like)domain.&Contains1ITAMdomain. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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